dc.contributor.author |
O'Grady, Gregory |
en |
dc.contributor.author |
Du, Peng |
en |
dc.contributor.author |
Lammers, Willem |
en |
dc.contributor.author |
Egbuji, John |
en |
dc.contributor.author |
Mithraratne, Pulasthi |
en |
dc.contributor.author |
Chen, JDZ |
en |
dc.contributor.author |
Cheng, Leo |
en |
dc.contributor.author |
Windsor, John |
en |
dc.contributor.author |
Pullan, Andrew |
en |
dc.date.accessioned |
2012-07-19T00:09:03Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
AJP - Gastrointestinal and Liver Physiology 298(2):G314-G321 2010 |
en |
dc.identifier.issn |
0193-1857 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/19362 |
en |
dc.description.abstract |
Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This study introduces high-resolution (HR) “entrainment mapping” for the analysis of gastric pacing and presents four demonstrations. Gastric pacing was initiated in a porcine model (typical amplitude 4 mA, pulse width 400 ms, period 17 s). Entrainment mapping was performed using flexible multielectrode arrays (≤192 electrodes; 92 cm2) and was analyzed using novel software methods. In the first demonstration, entrainment onset was quantified over successive waves in spatiotemporal detail. In the second demonstration, slow-wave velocity was accurately determined with HR field analysis, and paced propagation was found to be anisotropic (longitudinal 2.6 ± 1.7 vs. circumferential 4.5 ± 0.6 mm/s; P < 0.001). In the third demonstration, a dysrhythmic episode that occurred during pacing was mapped in HR, revealing an ectopic slow-wave focus and uncoupled propagations. In the fourth demonstration, differences were observed between paced and native slow-wave amplitudes (0.24 ± 0.08 vs. 0.38 ± 0.14 mV; P < 0.001), velocities (6.2 ± 2.8 vs. 11.5 ± 4.7 mm/s; P < 0.001), and activated areas (20.6 ± 1.9 vs. 32.8 ± 2.6 cm2; P < 0.001). Entrainment mapping enables an accurate quantification of the effects of gastric pacing on slow-wave activity, offering an improved method to assess whether pacing protocols are likely to achieve physiologically and clinically useful outcomes. |
en |
dc.publisher |
the American Physiological Society |
en |
dc.relation.ispartofseries |
American Journal of Physiology - Gastrointestinal and Liver Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0193-1857/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
High-resolution entrainment mapping of gastric pacing: a new analytical tool |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/ajpgi.00389.2009 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
G314 |
en |
pubs.volume |
298 |
en |
dc.rights.holder |
Copyright: the American Physiological Society |
en |
dc.identifier.pmid |
19926815 |
en |
pubs.end-page |
G321 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
101689 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19926815 |
en |