High-resolution entrainment mapping of gastric pacing: a new analytical tool

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dc.contributor.author O'Grady, Gregory en
dc.contributor.author Du, Peng en
dc.contributor.author Lammers, Willem en
dc.contributor.author Egbuji, John en
dc.contributor.author Mithraratne, Pulasthi en
dc.contributor.author Chen, JDZ en
dc.contributor.author Cheng, Leo en
dc.contributor.author Windsor, John en
dc.contributor.author Pullan, Andrew en
dc.date.accessioned 2012-07-19T00:09:03Z en
dc.date.issued 2010 en
dc.identifier.citation AJP - Gastrointestinal and Liver Physiology 298(2):G314-G321 2010 en
dc.identifier.issn 0193-1857 en
dc.identifier.uri http://hdl.handle.net/2292/19362 en
dc.description.abstract Gastric pacing has been investigated as a potential treatment for gastroparesis. New pacing protocols are required to improve symptom and motility outcomes; however, research progress has been constrained by a limited understanding of the effects of electrical stimulation on slow-wave activity. This study introduces high-resolution (HR) “entrainment mapping” for the analysis of gastric pacing and presents four demonstrations. Gastric pacing was initiated in a porcine model (typical amplitude 4 mA, pulse width 400 ms, period 17 s). Entrainment mapping was performed using flexible multielectrode arrays (≤192 electrodes; 92 cm2) and was analyzed using novel software methods. In the first demonstration, entrainment onset was quantified over successive waves in spatiotemporal detail. In the second demonstration, slow-wave velocity was accurately determined with HR field analysis, and paced propagation was found to be anisotropic (longitudinal 2.6 ± 1.7 vs. circumferential 4.5 ± 0.6 mm/s; P < 0.001). In the third demonstration, a dysrhythmic episode that occurred during pacing was mapped in HR, revealing an ectopic slow-wave focus and uncoupled propagations. In the fourth demonstration, differences were observed between paced and native slow-wave amplitudes (0.24 ± 0.08 vs. 0.38 ± 0.14 mV; P < 0.001), velocities (6.2 ± 2.8 vs. 11.5 ± 4.7 mm/s; P < 0.001), and activated areas (20.6 ± 1.9 vs. 32.8 ± 2.6 cm2; P < 0.001). Entrainment mapping enables an accurate quantification of the effects of gastric pacing on slow-wave activity, offering an improved method to assess whether pacing protocols are likely to achieve physiologically and clinically useful outcomes. en
dc.publisher the American Physiological Society en
dc.relation.ispartofseries American Journal of Physiology - Gastrointestinal and Liver Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0193-1857/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title High-resolution entrainment mapping of gastric pacing: a new analytical tool en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpgi.00389.2009 en
pubs.issue 2 en
pubs.begin-page G314 en
pubs.volume 298 en
dc.rights.holder Copyright: the American Physiological Society en
dc.identifier.pmid 19926815 en
pubs.end-page G321 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 101689 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19926815 en

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