Using Diffusion Tensor Imaging to Investigate How Brain Derived Neurotrophic Factor Genotype Influences Thalamo-Cortical Tracts

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dc.contributor.advisor Kirk, I en
dc.contributor.author Mckay, Nicole en
dc.date.accessioned 2013-03-10T20:44:31Z en
dc.date.issued 2013 en
dc.identifier.uri http://hdl.handle.net/2292/20195 en
dc.description Available to authenticated members of The University of Auckland. en
dc.description.abstract A single nucleotide polymorphism (SNP) in the gene coding for brain derived neurotrophic factor (BDNF) has previously been associated with variations in memory performance, learning ability, and hippocampal volume in humans. However, relatively little is known about the effects this polymorphism might have on connectivity via white matter pathways within the brain. Diffusion tensor imaging (DTI) has repeatedly been argued to be a valid method for investigating the integrity of white matter microstructure in vivo. Two thalamocortical tracts have been suggested to be particularly important to recognition memory. Here therefore, using probabilistic tractography on DTI-derived data, we compared the integrity of thalamo-cortical tracts in Val homozygotes and Met+ allele carriers of the BDNF gene. Participants also completed the visual memory subsets of the Wechsler Memory Scale-3rd edition (WMS-III). We found reduced connectivity in Met allele carriers, as measured by fractional anisotropy (FA) and mean diffusivity (MD), in thalamo-cortical tracts seeded from the anterior and medial dorsal thalamic nuclei. However, no difference was found in performance on recognition memory tasks. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ en
dc.title Using Diffusion Tensor Imaging to Investigate How Brain Derived Neurotrophic Factor Genotype Influences Thalamo-Cortical Tracts en
dc.type Thesis en
thesis.degree.discipline Psychology en
thesis.degree.grantor The University of Auckland en
thesis.degree.level Masters en
dc.rights.holder Copyright: The Author en
pubs.elements-id 374252 en
pubs.org-id Science en
pubs.org-id Psychology en
pubs.record-created-at-source-date 2013-03-11 en


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