Injectable implants for the sustained release of protein and peptide drugs

Show simple item record Agarwal, P en Rupenthal, Ilva en 2013-06-26T00:06:16Z en 2013-04 en
dc.identifier.citation Drug Discovery Today 18(7-8):337-349 Apr 2013 en
dc.identifier.issn 1359-6446 en
dc.identifier.uri en
dc.description.abstract Protein and peptide macromolecules have emerged as promising therapeutic agents in recent years. However, their delivery to the target site can be challenging owing to their susceptibility to denaturation and degradation, short half-life and, therefore, poor bioavailability. In situ-forming implants present an attractive parenteral delivery platform for proteins and peptides because of their ease of application, sustained-release properties, tissue biocompatibility and simple manufacture. In this review, we discuss the various mechanisms by which polymer systems assemble in situ to form implant devices for sustained release of therapeutic macromolecules, and highlight recent advances in polymer systems that gel in response to a combination of these mechanisms. Finally, we examine release mechanisms, marketed products and limitations of injectable implants. © 2013 Elsevier Ltd. en
dc.relation.ispartofseries Drug Discovery Today en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details taken from en
dc.rights.uri en
dc.title Injectable implants for the sustained release of protein and peptide drugs en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.drudis.2013.01.013 en
pubs.issue 7-8 en
pubs.begin-page 337 en
pubs.volume 18 en
pubs.end-page 349 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 379428 en Medical and Health Sciences en School of Medicine en Ophthalmology Department en
dc.identifier.eissn 1878-5832 en
pubs.record-created-at-source-date 2013-06-26 en

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