dc.contributor.author |
Agarwal, P |
en |
dc.contributor.author |
Rupenthal, Ilva |
en |
dc.date.accessioned |
2013-06-26T00:06:16Z |
en |
dc.date.issued |
2013-04 |
en |
dc.identifier.citation |
Drug Discovery Today 18(7-8):337-349 Apr 2013 |
en |
dc.identifier.issn |
1359-6446 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/20545 |
en |
dc.description.abstract |
Protein and peptide macromolecules have emerged as promising therapeutic agents in recent years. However, their delivery to the target site can be challenging owing to their susceptibility to denaturation and degradation, short half-life and, therefore, poor bioavailability. In situ-forming implants present an attractive parenteral delivery platform for proteins and peptides because of their ease of application, sustained-release properties, tissue biocompatibility and simple manufacture. In this review, we discuss the various mechanisms by which polymer systems assemble in situ to form implant devices for sustained release of therapeutic macromolecules, and highlight recent advances in polymer systems that gel in response to a combination of these mechanisms. Finally, we examine release mechanisms, marketed products and limitations of injectable implants. © 2013 Elsevier Ltd. |
en |
dc.relation.ispartofseries |
Drug Discovery Today |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details taken from http://www.sherpa.ac.uk/romeo/issn/1359-6446/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Injectable implants for the sustained release of protein and peptide drugs |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.drudis.2013.01.013 |
en |
pubs.issue |
7-8 |
en |
pubs.begin-page |
337 |
en |
pubs.volume |
18 |
en |
pubs.end-page |
349 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
379428 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1878-5832 |
en |
pubs.record-created-at-source-date |
2013-06-26 |
en |