dc.contributor.author |
Berry, MJ |
en |
dc.contributor.author |
Jaquiery, Anne |
en |
dc.contributor.author |
Oliver, Mark |
en |
dc.contributor.author |
Harding, Jane |
en |
dc.contributor.author |
Bloomfield, Francis |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2013-08-16T03:09:55Z |
en |
dc.date.issued |
2013-07 |
en |
dc.identifier.citation |
Acta Obstetricia et Gynecologica Scandinavica 92(7):862-865 Jul 2013 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/20699 |
en |
dc.description.abstract |
Clinical practice guidelines for elective cesarean section at early-term gestation (37-38 weeks) recommend antenatal corticosteroids to reduce neonatal respiratory morbidity. However, the long-term health implications for offspring exposed to corticosteroids at term are unknown and may differ from the effects of preterm corticosteroid exposure. We therefore randomized singleton-bearing ewes (n = 64) to receive a clinically relevant dose of corticosteroids at term or no treatment. Body composition was assessed in adult offspring using dual-energy X-ray absorptiometry. Relative to skeletal size female, but not male, offspring of steroid-treated ewes had increased weight and a greater fat mass than controls (relative weight: 49.1 ± 1.1 vs. 52.9 ± 1.2 kg/m(2) , p = 0.02; relative fat mass: 5.4 ± 0.7 vs. 3.4 ± 0.7 kg/m(2) , p = 0.04). Whether corticosteroid exposure at early-term gestation increases adult adiposity in humans is unknown and needs further investigation. |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Acta Obstetricia et Gynecologica Scandinavica |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0001-6349/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Antenatal corticosteroid exposure at term increases adult adiposity: an experimental study in sheep |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/aogs.12149 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
862 |
en |
pubs.volume |
92 |
en |
dc.identifier.pmid |
23663068 |
en |
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/23663068 |
en |
pubs.end-page |
865 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
379846 |
en |
pubs.org-id |
Liggins Institute |
en |
pubs.org-id |
LiFePATH |
en |
dc.identifier.eissn |
1600-0412 |
en |
pubs.record-created-at-source-date |
2013-08-16 |
en |
pubs.dimensions-id |
23663068 |
en |