Environment-sensitive polymers for ophthalmic drug delivery

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dc.contributor.author Thrimawithana, TR en
dc.contributor.author Rupenthal, Ilva en
dc.contributor.author Young, SA en
dc.contributor.author Alany, Raid en
dc.date.accessioned 2013-09-26T23:20:56Z en
dc.date.issued 2012 en
dc.identifier.citation Journal of Drug Delivery Science and Technology 22(2):117-124 Mar 2012 en
dc.identifier.issn 1773-2247 en
dc.identifier.uri http://hdl.handle.net/2292/20800 en
dc.description.abstract Ophthalmic drug delivery is a challenging endeavor for pharmaceutical scientists, owing to many physiological barriers of the eye. Ocular drugs are often formulated as solutions, but the precorneal drainage, lymphatic clearance, tearing and corneal barrier restrict the bioavailability of the administered drug. Consequently, in situ forming gels have been investigated by many to improve the ocular bioavailability of the administered drug. In situ gelling systems are formulated with stimuli-sensitive polymers. These polymeric systems are liquid at room temperature, but undergo sol-gel transition on the ocular surface. This phenomenon enhances the ocular retention of the administered drug and also provides sustained release of the incorporated drug - both of which reduce the frequency of drug administration required for effective management of ocular diseases. This review article summarizes the various polymers that undergo sol-gel transition owing to physical (temperature, light) or chemical (ions, pH) stimuli on the eye. en
dc.relation.ispartofseries Journal of Drug Delivery Science and Technology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1773-2247/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Environment-sensitive polymers for ophthalmic drug delivery en
dc.type Journal Article en
dc.identifier.doi 10.1016/S1773-2247(12)50015-8 en
pubs.issue 2 en
pubs.begin-page 117 en
pubs.volume 22 en
pubs.end-page 124 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 344760 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Ophthalmology Department en
pubs.record-created-at-source-date 2012-12-05 en


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