dc.contributor.author |
Hughes, Jacelyn |
en |
dc.contributor.author |
Adenwalla, N |
en |
dc.contributor.author |
Wiles, Siouxsie |
en |
dc.contributor.author |
Proft, Thomas |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2013-09-27T00:36:55Z |
en |
dc.date.issued |
2013-07-01 |
en |
dc.identifier.citation |
Virulence 4(5):419-428 01 Jul 2013 |
en |
dc.identifier.issn |
2150-5594 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/20806 |
en |
dc.description.abstract |
Group A streptococcus is a strict human pathogen that can cause a wide range of diseases, such as tonsillitis, impetigo, necrotizing fasciitis, toxic shock, and acute rheumatic fever. Modeling human diseases in animals is complicated, and rapid, simple, and cost-effective in vivo models of GAS infection are clearly lacking. Recently, the use of non-mammalian models to model human disease is starting to re-attract attention. Galleria mellonella larvae, also known as wax worms, have been investigated for modeling a number of bacterial pathogens, and have been shown to be a useful model to study pathogenesis of the M3 serotype of GAS. In this study we provide further evidence of the validity of the wax worm model by testing different GAS M-types, as well as investigating the effect of bacterial growth phase and incubation temperature on GAS virulence in this model. In contrast to previous studies, we show that the M-protein, among others, is an important virulence factor that can be effectively modeled in the wax worm. We also highlight the need for a more in-depth investigation of the effects of experimental design and wax worm supply before we can properly vindicate the wax worm model for studying GAS pathogenesis. |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Virulence |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.landesbioscience.com/journals/cc/guidelines/ http://www.sherpa.ac.uk/romeo/issn/2150-5594/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Galleria mellonellalarvae |
en |
dc.subject |
Streptococcus pyogenes |
en |
dc.subject |
group A streptococcus |
en |
dc.subject |
in vivo |
en |
dc.subject |
infection model |
en |
dc.subject |
wax worms |
en |
dc.title |
Galleria mellonella larvae as an infection model for group A streptococcus |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.4161/viru.24930 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
419 |
en |
pubs.volume |
4 |
en |
dc.identifier.pmid |
23652836 |
en |
pubs.end-page |
428 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
379907 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2150-5608 |
en |
dc.identifier.pii |
24930 |
en |
pubs.record-created-at-source-date |
2013-09-27 |
en |
pubs.dimensions-id |
23652836 |
en |