dc.contributor.author |
Lei, L |
en |
dc.contributor.author |
Altstaedt, J |
en |
dc.contributor.author |
von der Ohe, M |
en |
dc.contributor.author |
Proft, Thomas |
en |
dc.contributor.author |
Gross, U |
en |
dc.contributor.author |
Rink, L |
en |
dc.date.accessioned |
2013-10-02T22:39:15Z |
en |
dc.date.issued |
2001-07-01 |
en |
dc.identifier.citation |
Journal of Leukocyte Biology 70(1):80-86 01 Jul 2001 |
en |
dc.identifier.issn |
0741-5400 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/20836 |
en |
dc.description.abstract |
Neutrophils have been shown to express major histocompatibility complex class II (MHC II) after stimulation. However, reports concerning the functional effect of MCH II expression are still lacking. In our hands, granulocyte-monocyte colony-stimulating factor (GM-CSF) alone and in combination with interferon (IFN)-gamma, but not IFN-gamma or interleukin (IL)-3, induced a significant level of expression of human leukocyte antigen DR on neutrophils. The addition of staphylococcal enterotoxin E to neutrophils resulted in a significant increase in IL-8 production only after prestimulation with GM-CSF alone or in combination with IFN-gamma but had no effect on neutrophils preincubated with IFN-gamma alone or IL-3. Staphylococcal enterotoxin A, another bivalent superantigen, also stimulated production of IL-8 by preincubated polymorphonuclear neutrophils, whereas staphylococcal enterotoxin A mutants that are not able to cross-link MHC II molecules failed to induce IL-8 production. Taken together, our results clearly demonstrate that after induction of MHC II, neutrophils are able to respond to MHC II-specific stimulation. These findings support the ideas that the induced MHC II complex is completely functional and that neutrophils may be able to present antigens. |
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dc.language |
English |
en |
dc.publisher |
FEDERATION AMER SOC EXP BIOL |
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dc.relation.ispartofseries |
Journal of Leukocyte Biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.jleukbio.org/site/misc/copyright.xhtml http://www.sherpa.ac.uk/romeo/issn/0741-5400/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Cell Biology |
en |
dc.subject |
Hematology |
en |
dc.subject |
Immunology |
en |
dc.subject |
major histocompatibility complex (MHC) |
en |
dc.subject |
neutrophils |
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dc.subject |
superantigens |
en |
dc.subject |
STAPHYLOCOCCAL-ENTEROTOXIN-A |
en |
dc.subject |
COMPLEX CLASS-II |
en |
dc.subject |
COLONY-STIMULATING FACTOR |
en |
dc.subject |
T-CELL ACTIVATION |
en |
dc.subject |
RHEUMATOID-ARTHRITIS |
en |
dc.subject |
POLYMORPHONUCLEAR NEUTROPHILS |
en |
dc.subject |
MOLECULES |
en |
dc.subject |
EXPRESSION |
en |
dc.subject |
GRANULOCYTES |
en |
dc.subject |
MONOCYTES |
en |
dc.title |
Induction of interleukin-8 in human neutrophils after MHC class II cross-linking with superantigens |
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dc.type |
Journal Article |
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pubs.issue |
1 |
en |
pubs.begin-page |
80 |
en |
pubs.volume |
70 |
en |
dc.identifier.pmid |
11435489 |
en |
pubs.author-url |
http://www.jleukbio.org/content/70/1/80 |
en |
pubs.end-page |
86 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
206732 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2013-10-03 |
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pubs.dimensions-id |
11435489 |
en |