dc.contributor.author |
Arcus, VL |
en |
dc.contributor.author |
Langley, Ries |
en |
dc.contributor.author |
Proft, Thomas |
en |
dc.contributor.author |
Fraser, John |
en |
dc.contributor.author |
Baker, Edward |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2013-10-03T00:46:49Z |
en |
dc.date.issued |
2002-08-30 |
en |
dc.identifier.citation |
Journal of Biological Chemistry 277(35):32274-32281 30 Aug 2002 |
en |
dc.identifier.issn |
0021-9258 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/20854 |
en |
dc.description.abstract |
The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions. |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of Biological Chemistry |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.jbc.org/site/misc/Copyright_Permission.xhtml http://www.sherpa.ac.uk/romeo/search.php?issn=0021-9258 |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Amino Acid Sequence |
en |
dc.subject |
Bacterial Proteins |
en |
dc.subject |
Binding Sites |
en |
dc.subject |
Crystallography, X-Ray |
en |
dc.subject |
Humans |
en |
dc.subject |
Lymphocyte Activation |
en |
dc.subject |
Models, Molecular |
en |
dc.subject |
Molecular Sequence Data |
en |
dc.subject |
Protein Conformation |
en |
dc.subject |
Sequence Alignment |
en |
dc.subject |
Sequence Homology, Amino Acid |
en |
dc.subject |
Staphylococcus aureus |
en |
dc.subject |
Superantigens |
en |
dc.subject |
T-Lymphocytes |
en |
dc.subject |
Virulence |
en |
dc.title |
The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1074/jbc.M203914200 |
en |
pubs.issue |
35 |
en |
pubs.begin-page |
32274 |
en |
pubs.volume |
277 |
en |
dc.identifier.pmid |
12082105 |
en |
pubs.end-page |
32281 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
5082 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1083-351X |
en |
dc.identifier.pii |
M203914200 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
12082105 |
en |