Milk protein for improved metabolic health: a review of the evidence

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Show simple item record McGregor, Robin en Poppitt, Sally en 2013-11-07T02:24:00Z en 2013-07-03 en
dc.identifier.citation Nutrition and Metabolism, 10(1):46 03 Jul 2013 en
dc.identifier.issn 1743-7075 en
dc.identifier.uri en
dc.description.abstract Epidemiological evidence shows that consumption of dairy products is associated with decreased prevalence of metabolic related disorders, whilst evidence from experimental studies points towards dairy protein as a dietary component which may aid prevention of type 2 diabetes (T2DM). Poor metabolic health is a common characteristic of overweight, obesity and aging, and is the forerunner of T2DM and cardiovascular disease (CVD), and an ever increasing global health issue. Progressive loss of metabolic control is evident from a blunting of carbohydrate, fat and protein metabolism, which is commonly manifested through decreased insulin sensitivity, inadequate glucose and lipid control, accompanied by a pro-inflammatory environment and hypertension. Adverse physiological changes such as excess visceral adipose tissue deposition and expansion, lipid overspill and infiltration into liver, muscle and other organs, and sarcopaenia or degenerative loss of skeletal muscle mass and function all underpin this adverse profile. 'Sarcobesity' and sarcopaenic diabetes are rapidly growing health issues. As well as through direct mechanisms, dairy protein may indirectly improve metabolic health by aiding loss of body weight and fat mass through enhanced satiety, whilst promoting skeletal muscle growth and function through anabolic effects of dairy protein-derived branch chain amino acids (BCAAs). BCAAs enhance muscle protein synthesis, lean body mass and skeletal muscle metabolic function. The composition and processing of dairy protein has an impact on digestion, absorption, BCAA kinetics and function, hence the optimisation of dairy protein composition through selection and combination of specific protein components in milk may provide a way to maximize benefits for metabolic health. en
dc.relation.ispartofseries Nutrition and Metabolism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
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dc.title Milk protein for improved metabolic health: a review of the evidence en
dc.type Journal Article en
dc.identifier.doi 10.1186/1743-7075-10-46 en
pubs.issue 1 en
pubs.volume 10 en
dc.identifier.pmid 23822206 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 407277 en Science en Biological Sciences en
dc.identifier.eissn 1743-7075 en
pubs.number 46 en
pubs.record-created-at-source-date 2013-10-09 en
pubs.dimensions-id 23822206 en

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