Carbohydrate in the mouth enhances activation of brain circuitry involved in motor performance and sensory perception

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dc.contributor.author Turner, Clare en
dc.contributor.author Byblow, Winston en
dc.contributor.author Stinear, Cathy en
dc.contributor.author Gant, Nicholas en
dc.date.accessioned 2014-06-30T03:35:36Z en
dc.date.issued 2014-09-01 en
dc.identifier.citation Appetite, 2014, 80 pp. 212 - 219 en
dc.identifier.issn 0195-6663 en
dc.identifier.uri http://hdl.handle.net/2292/22362 en
dc.description.abstract The presence of carbohydrate in the human mouth has been associated with the facilitation of motor output and improvements in physical performance. Oral receptors have been identified as a potential mode of afferent transduction for this novel form of nutrient signalling that is distinct from taste. In the current study oral exposure to carbohydrate was combined with a motor task in a neuroimaging environment to identify areas of the brain involved in this phenomenon. A mouth-rinsing protocol was conducted whilst carbohydrate (CHO) and taste-matched placebo (PLA) solutions were delivered and recovered from the mouths of 10 healthy volunteers within a double-blind, counterbalanced design. This protocol eliminates post-oral factors and controls for the perceptual qualities of solutions. Functional magnetic resonance imaging of the brain was used to identify cortical areas responsive to oral carbohydrate during rest and activity phases of a hand-grip motor task. Mean blood-oxygen-level dependent signal change expe- rienced in the contralateral primary sensorimotor cortex was larger for CHO compared with PLA during the motor task when contrasted with a control condition. Areas of activation associated with CHO exclusively were observed over the primary taste cortex and regions involved in visual perception. Regions in the limbic system associated with reward were also significantly more active with CHO. This is the first demonstration that oral carbohydrate signalling can increase activation within the primary sensorimotor cortex during physical activity and enhance activation of neural networks involved in sensory perception. en
dc.relation.ispartofseries Appetite en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0195-6663/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Carbohydrate in the mouth enhances activation of brain circuitry involved in motor performance and sensory perception en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.appet.2014.05.020 en
pubs.begin-page 212 en
pubs.volume 80 en
dc.identifier.pmid 24858834 en
pubs.author-url http://www.sciencedirect.com/science/article/pii/S0195666314002281 en
pubs.end-page 219 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 440075 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1095-8304 en
pubs.record-created-at-source-date 2014-05-28 en
pubs.dimensions-id 24858834 en


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