dc.contributor.author |
Arroll, Bruce |
en |
dc.contributor.author |
Kenealy, Timothy |
en |
dc.contributor.author |
Falloon, KF |
en |
dc.date.accessioned |
2014-09-08T04:57:47Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
New Zealand Medical Journal, 2008, 121 (1284), pp. 64 - 70 |
en |
dc.identifier.issn |
0028-8446 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/22879 |
en |
dc.description.abstract |
AIM: To determine the effect of antibiotic treatment versus placebo in patients with acute upper respiratory tract infections. METHODS: A systematic review and meta-analysis examined the effect of antibiotics versus placebo in randomised controlled trials to initially treat acute upper respiratory tract infections. RESULTS: Eight studies of children from age 6 months and adults up to the age of 49 years were found. The main outcome measures were general improvement and adverse effects. No benefit was demonstrated in terms of overall improvement from the use of antibiotics compared to placebo for patients with acute upper respiratory tract infections RR=0.89 (95%CI 0.77-1.04). There was also a significant increase in adverse effects (mainly gastrointestinal) using a random effects model with a relative risk RR=2.71 (95%CI 1.08-6.83). CONCLUSIONS: Initial use of antibiotics do not benefit patients with acute upper respiratory tract infections and are associated with an increase in adverse effects. |
en |
dc.relation.ispartofseries |
New Zealand Medical Journal |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Are antibiotics indicated as an initial treatment for patients with acute upper respiratory tract infections? A review |
en |
dc.type |
Journal Article |
en |
pubs.issue |
1284 |
en |
pubs.begin-page |
64 |
en |
pubs.volume |
121 |
en |
dc.identifier.pmid |
18953388 |
en |
pubs.author-url |
http://www.nzma.org.nz/__data/assets/pdf_file/0003/17805/Vol-121-No-1284-17-October-2008.pdf |
en |
pubs.end-page |
70 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
77655 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Gen.Practice& Primary Hlthcare |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Cent Medical & Hlth Sci Educat |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.eissn |
1175-8716 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18953388 |
en |