dc.contributor.author |
Leung, Yee Fun |
en |
dc.contributor.author |
Hong, Jiwon |
en |
dc.contributor.author |
Fraser, Alan |
en |
dc.contributor.author |
Merriman, TR |
en |
dc.contributor.author |
Vishnu, P |
en |
dc.contributor.author |
Krissansen, Geoffrey |
en |
dc.date.accessioned |
2014-09-09T02:56:27Z |
en |
dc.date.issued |
2006-04 |
en |
dc.identifier.citation |
Immunology and cell biology, 2006, 84 (2), pp. 233 - 236 |
en |
dc.identifier.issn |
0818-9641 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/22890 |
en |
dc.description.abstract |
Polymorphisms in the organic cation transporter (OCTN) genes SLC22A4 (OCTN1; polymorphism 1672C/T) and SLC22A5 (OCTN2; polymorphism -207G/C) at the inflammatory bowel disease (IBD) 5 locus comprise a two-allele haplotype (SLC22A-TC) associated with increased risk for Crohn's disease (CD). In this study, we examined the contribution of the disease susceptibility haplotype SLC22A-TC to CD in a New Zealand Caucasian population. The frequencies of the gene polymorphisms 1672C/T and -207G/C were examined in 182 patients with CD and 188 ethnically matched controls by PCR-RFLP analysis. There was a significant difference in the allele frequency (0.444 vs 0.519; P = 0.041) of the 1672T polymorphism in the SLC22A4 gene between controls and patients with CD. In contrast, there was no significant difference (0.497 vs 0.552; P = 0.135) for the -207C polymorphism in the SLC22A5 gene. The homozygote SLC22A-TC diplotype was significantly associated with an increased risk for CD (odds ratio 2.19), and the SLC22A-TC haplotype was associated with increased risk (P = 0.0007) of ileocolonic involvement. The population-attributable risk for the SLC22A-TC haplotype is 15.1%. Thus, SLC22A-TC is associated with an increased risk of CD and disease phenotype in our New Zealand CD cohort. |
en |
dc.language |
EN |
en |
dc.publisher |
Blackwell Publishing |
en |
dc.relation.ispartofseries |
Immunology and cell biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.nature.com/authors/policies/license.html http://www.sherpa.ac.uk/romeo/issn/0818-9641/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Crohn's disease |
en |
dc.subject |
organic cation transporter |
en |
dc.subject |
polymorphism |
en |
dc.subject |
susceptibility gene |
en |
dc.subject |
SUSCEPTIBILITY LOCI |
en |
dc.subject |
HAPLOTYPE |
en |
dc.subject |
ASSOCIATION |
en |
dc.subject |
VARIANTS |
en |
dc.subject |
SEARCH |
en |
dc.subject |
RISK |
en |
dc.subject |
DLG5 |
en |
dc.title |
Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/j.1440-1711.2006.01423.x |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
233 |
en |
pubs.volume |
84 |
en |
dc.rights.holder |
Copyright:
Blackwell Publishing |
en |
dc.identifier.pmid |
16519742 |
en |
pubs.end-page |
236 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
111495 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
dc.identifier.eissn |
1440-1711 |
en |
pubs.record-created-at-source-date |
2014-09-09 |
en |
pubs.dimensions-id |
16519742 |
en |