When is acute persistent cough in school-age children and adults whooping cough? A prospective case series study.

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dc.contributor.author Philipson, K en
dc.contributor.author Goodyear-Smith, Felicity en
dc.contributor.author Grant, Cameron en
dc.contributor.author Chong, Angela en
dc.contributor.author Turner, Nicola en
dc.contributor.author Stewart, Joanna en
dc.date.accessioned 2014-09-23T03:31:59Z en
dc.date.issued 2013-08 en
dc.identifier.citation British Journal of General Practice, 2013, 63 (613), pp. e573 - e579 en
dc.identifier.issn 0960-1643 en
dc.identifier.uri http://hdl.handle.net/2292/23003 en
dc.description.abstract BACKGROUND: Pertussis is a vaccine modified disease in most age groups and hence subtle in its presentation. Current diagnostic approaches require relatively invasive sampling. AIM: To determine the incidence of B. pertussis infection among people aged 5-49 years identified in primary care with acute persistent cough using an oral fluid based diagnostic test. DESIGN AND SETTING: Active surveillance of acute persistent cough of 2 weeks duration or greater was established in Auckland, New Zealand from May to October 2011. The 15 participating primary care practices provided care for a socioeconomically diverse population. METHOD: Recent B. pertussis infection was determined by measurement of IgG antibodies to pertussis toxin (PT) in an oral fluid sample. An IgG antibody titre to PT of ≥70 arbitrary units defined recent infection. Participants reported symptoms at presentation and kept a cough diary. RESULTS: A total of 226 participants were enrolled: 70 (31%) were children (5-16 years) and 156 (69%) were adults (17-49 years). Oral fluid samples were obtained from 225 participants. Ten per cent (23/225) had recent B. pertussis infection including a larger proportion of children than adults (17% versus 7%, P = 0.003). Neither cough duration nor any individual symptom discriminated between those with and without recent B. pertussis infection. CONCLUSION: Pertussis is a frequent cause of acute persistent cough presenting to primary care. Clinical differentiation of pertussis from other causes of acute persistent cough is difficult. An oral fluid based diagnostic test, which is less invasive than other diagnostic approaches, has high acceptability in primary care. en
dc.format.medium Print en
dc.language eng en
dc.relation.ispartofseries British Journal of General Practice en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://bjgp.org/authors/bjgp-editorial-process-and-policies http://www.sherpa.ac.uk/romeo/issn/0960-1643/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Bordetella pertussis en
dc.subject Whooping Cough en
dc.subject Cough en
dc.subject Chronic Disease en
dc.subject Antibodies, Bacterial en
dc.subject Diagnosis, Differential en
dc.subject Enzyme-Linked Immunosorbent Assay en
dc.subject Prospective Studies en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Middle Aged en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Female en
dc.subject Male en
dc.subject Young Adult en
dc.title When is acute persistent cough in school-age children and adults whooping cough? A prospective case series study. en
dc.type Journal Article en
dc.identifier.doi 10.3399/bjgp13x670705 en
pubs.issue 613 en
pubs.begin-page e573 en
pubs.volume 63 en
dc.identifier.pmid 23972198 en
pubs.end-page e579 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 405987 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Gen.Practice& Primary Hlthcare en
pubs.org-id School of Medicine en
pubs.org-id Paediatrics Child & Youth Hlth en
dc.identifier.eissn 1478-5242 en
pubs.record-created-at-source-date 2014-09-23 en
pubs.dimensions-id 23972198 en

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