Chitosan for overweight or obesity

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dc.contributor.author Jull, Andrew en
dc.contributor.author Ni Mhurchu, Cliona en
dc.contributor.author Bennett, DA en
dc.contributor.author Dunshea-Mooij, Christel en
dc.contributor.author Rodgers, Anthony en
dc.date.accessioned 2014-10-20T03:08:41Z en
dc.date.issued 2008 en
dc.identifier.citation Cochrane Database of Systematic Reviews, 2008, (3) en
dc.identifier.issn 1469-493X en
dc.identifier.uri http://hdl.handle.net/2292/23276 en
dc.description.abstract Background: Chitosan, a deacetylated chitin, is a dietary supplement reported to decrease body weight. It is widely available over the counter worldwide and although evaluated in a number of trials its efficacy remains in dispute. Objectives: To assess the effects of chitosan as a treatment for overweight and obesity. Search strategy: We searched electronic databases (MEDLINE, EMBASE, BIOSIS, CINAHL, The Cochrane Library), specialised web sites (Controlled Trials, IBIDS, SIGLE, Reuter’s Health Service, Natural Alternatives International, Pharmanutrients), bibliographies of relevant journal articles, and contacted relevant authors and manufacturers. Selection criteria: Trials were included in the review if they were randomised controlled trials of chitosan for a minimum of four weeks duration in adults who were overweight or obese. Authors of included studies were contacted for additional information where appropriate. Data collection and analysis: Details from eligible trials were extracted independently by two reviewers using a standardised data extraction form. Differences in data extraction were resolved by consensus. Continuous data were expressed as weighted mean differences and standard deviations. The pooled effect size was computed by using the inverse variance weighted method. Main results: Fifteen trials including a total of 1219 participants met the inclusion criteria. No trial to date has measured the effect of chitosan on mortality or morbidity. Analyses indicated that chitosan preparations result in a significantly greater weight loss (weighted mean difference -1.7 kg; 95%confidence interval (CI) -2.1 to -1.3 kg, P < 0.00001), decrease in total cholesterol (-0.2 mmol/L [95% CI -0.3 to -0.1], P < 0.00001), and a decrease in systolic and diastolic blood pressure compared with placebo. There were no clear differences between intervention and control groups in terms of frequency of adverse events or in faecal fat excretion. However, the quality of many studies was sub-optimal and analyses restricted to studies that met allocation concealment criteria, were larger, or of longer duration showed that such trials produced substantially smaller decreases in weight and total cholesterol. Authors’ conclusions: There is some evidence that chitosan is more effective than placebo in the short-term treatment of overweight and obesity. However, many trials to date have been of poor quality and results have been variable. Results obtained from high quality trials indicate that the effect of chitosan on body weight is minimal and unlikely to be of clinical significance. en
dc.language EN en
dc.publisher Wiley & Sons en
dc.relation.ispartofseries Cochrane Database of Systematic Reviews en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.thecochranelibrary.com/view/0/PermissionsReprints.html http://www.sherpa.ac.uk/romeo/issn/1469-493X/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Chitosan en
dc.subject Obesity en
dc.subject Weight management en
dc.subject Nutraceuticals en
dc.subject Systematic review en
dc.subject Meta-analysis en
dc.title Chitosan for overweight or obesity en
dc.type Journal Article en
dc.identifier.doi 10.1002/14651858.CD003892.pub3 en
pubs.issue 3 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: Wiley & Sons en
dc.identifier.pmid 18646097 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 81853 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Nursing en
pubs.org-id Population Health en
pubs.org-id Pacific Health en
pubs.number CD003892 en
pubs.record-created-at-source-date 2010-11-29 en
pubs.dimensions-id 18646097 en


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