dc.contributor.author |
MacDonald, HJ |
en |
dc.contributor.author |
Coxon, JP |
en |
dc.contributor.author |
Stinear, Cathy |
en |
dc.contributor.author |
Byblow, Winston |
en |
dc.date.accessioned |
2014-11-13T02:55:51Z |
en |
dc.date.issued |
2014-12 |
en |
dc.identifier.citation |
Journal of neurophysiology 112(11):2707-2717 Dec 2014 |
en |
dc.identifier.issn |
0022-3077 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/23476 |
en |
dc.description.abstract |
The sudden cancellation of a motor action, known as response inhibition (RI), is fundamental to human motor behavior. The behavioral selectivity of RI can be studied by cueing cancellation of only a subset of a planned response, which markedly delays the remaining executed components. The present study examined neurophysiological mechanisms that may contribute to these delays. In two experiments, human participants received single- and paired-pulse transcranial magnetic stimulation while performing a bimanual anticipatory response task. Participants performed most trials bimanually (Go trials) and were sometimes cued to cancel the response with one hand while responding with the other (Partial trials). Motor evoked potentials were recorded from left first dorsal interosseous (FDI) as a measure of corticomotor excitability (CME) during Go and Partial trials. CME was temporally modulated during Partial trials in a manner that reflected anticipation, suppression, and subsequent initiation of a reprogrammed response. There was an initial increase in CME, followed by suppression 175 ms after the stop signal, even though the left hand was not cued to stop. A second increase in excitability occurred prior to the (delayed) response. We propose an activation threshold model to account for nonselective RI. To investigate the inhibitory component of our model, we investigated short-latency intracortical inhibition (sICI), but results indicated that sICI cannot fully explain the observed temporal modulation of CME. These neurophysiological and behavioural results indicate that the default mode for reactive partial cancellation is suppression of a unitary response, followed by response reinitiation with an inevitable time delay. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Journal of neurophysiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3077/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Motor Cortex |
en |
dc.subject |
Humans |
en |
dc.subject |
Psychomotor Performance |
en |
dc.subject |
Reaction Time |
en |
dc.subject |
Evoked Potentials, Motor |
en |
dc.subject |
Neural Inhibition |
en |
dc.subject |
Models, Neurological |
en |
dc.subject |
Adult |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
The fall and rise of corticomotor excitability with cancellation and reinitiation of prepared action. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/jn.00366.2014 |
en |
pubs.issue |
11 |
en |
pubs.begin-page |
2707 |
en |
pubs.volume |
112 |
en |
dc.identifier.pmid |
25185817 |
en |
pubs.end-page |
2717 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
en |
pubs.subtype |
Journal Article |
en |
pubs.elements-id |
456327 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Exercise Sciences |
en |
dc.identifier.eissn |
1522-1598 |
en |
pubs.record-created-at-source-date |
2014-12-02 |
en |
pubs.dimensions-id |
25185817 |
en |