Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity.

Show simple item record

dc.contributor.author Angeli, Timothy en
dc.contributor.author O'Grady, Gregory en
dc.contributor.author Paskaranandavadivel, Niranchan en
dc.contributor.author Erickson, JC en
dc.contributor.author Du, Peng en
dc.contributor.author Pullan, AJ en
dc.contributor.author Bissett, Ian en
dc.contributor.author Cheng, Leo en
dc.date.accessioned 2014-11-17T22:18:12Z en
dc.date.issued 2013-04 en
dc.identifier.citation Journal of Neurogastroenterology and Motility, 2013, 19 (2), pp. 179 - 191 en
dc.identifier.issn 2093-0879 en
dc.identifier.uri http://hdl.handle.net/2292/23505 en
dc.description.abstract BACKGROUND/AIMS: Small intestine motility is governed by an electrical slow wave activity, and abnormal slow wave events have been associated with intestinal dysmotility. High-resolution (HR) techniques are necessary to analyze slow wave propagation, but progress has been limited by few available electrode options and laborious manual analysis. This study presents novel methods for in vivo HR mapping of small intestine slow wave activity. METHODS: Recordings were obtained from along the porcine small intestine using flexible printed circuit board arrays (256 electrodes; 4 mm spacing). Filtering options were compared, and analysis was automated through adaptations of the falling-edge variable-threshold (FEVT) algorithm and graphical visualization tools. RESULTS: A Savitzky-Golay filter was chosen with polynomial-order 9 and window size 1.7 seconds, which maintained 94% of slow wave amplitude, 57% of gradient and achieved a noise correction ratio of 0.083. Optimized FEVT parameters achieved 87% sensitivity and 90% positive-predictive value. Automated activation mapping and animation successfully revealed slow wave propagation patterns, and frequency, velocity, and amplitude were calculated and compared at 5 locations along the intestine (16.4 ± 0.3 cpm, 13.4 ± 1.7 mm/sec, and 43 ± 6 µV, respectively, in the proximal jejunum). CONCLUSIONS: The methods developed and validated here will greatly assist small intestine HR mapping, and will enable experimental and translational work to evaluate small intestine motility in health and disease. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.relation.ispartofseries Journal of Neurogastroenterology and Motility en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity. en
dc.type Journal Article en
dc.identifier.doi 10.5056/jnm.2013.19.2.179 en
pubs.issue 2 en
pubs.begin-page 179 en
pubs.volume 19 en
dc.identifier.pmid 23667749 en
pubs.end-page 191 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 379915 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
dc.identifier.eissn 2093-0887 en
pubs.record-created-at-source-date 2014-11-18 en
pubs.dimensions-id 23667749 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace