dc.contributor.author |
McCowan, Lesley |
en |
dc.contributor.author |
Craigie, S |
en |
dc.contributor.author |
Taylor, Rennae |
en |
dc.contributor.author |
Ward, C |
en |
dc.contributor.author |
McLintock, C |
en |
dc.contributor.author |
North, RA |
en |
dc.date.accessioned |
2014-12-17T02:44:09Z |
en |
dc.date.issued |
2003-04 |
en |
dc.identifier.citation |
American Journal of Obstetrics and Gynecology, 2003, 188 (4), pp. 981 - 985 |
en |
dc.identifier.issn |
0002-9378 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/23835 |
en |
dc.description.abstract |
OBJECTIVE: The purpose of this study was to determine (1) whether the inherited thrombophilias (the factor V Leiden and prothrombin gene mutations and the methylenetetrahydrofolate reductase [C677T] polymorphism) are increased in women with "idiopathic" (normotensive) small-for-gestational -age pregnancies and/or in their babies and (2) whether fetal carriage of a thrombophilia is associated with abnormal umbilical Doppler studies.STUDY DESIGN: This was a case-controlled study of normotensive women who were delivered of a singleton small-for-gestational-age baby (birth weight, <10th percentile adjusted for sex) with no clinical evidence of chromosomal or congenital abnormality Control subjects were healthy women who were delivered of appropriate-for-gestational-age babies.RESULTS: One hundred forty-five women with small-for-gestational-age,pregnancies and 290 control subjects Were recruited. Small-for-gestational-age babies were born at an earlier gestational age (38 +/- 3.0 weeks) and with a lower birth weight (2373 521 g) than control babies (39.7 +/- 1.3 weeks and 3606 +/- 423 g, P <.01). There were no differences in the rates of factor V Leiden (2.8% vs 3.8%; relative risk, 0.79; 95% Cl, 0.34-1.85), prothrombin gene mutation (2.8% vs 3.1%; relative risk, 0.92; 95% Cl, 0.40-2.09), and methylenetetrahydrofolate reductase C677T polymorphism (13% vs 9%; relative risk, 1.27; 95% Cl, 0.87-1.84) between mothers with small-for-gestational-age babies and control subjects, respectively. Inherited thrombophilias were not increased in small-for-gestational-age babies compared with control babies. Of small-for-gestational-age babies with abnormal umbilical artery Doppler studies (n = 25), 21% had a thrombophilia compared with 11% with normal umbilical artery Doppler studies (n = 68; relative risk, 1.75; 95% Cl, 0.81-3.81).CONCLUSION: The rates of these inherited thrombophilias are not increased in normotensive women with small-for-gestational-age pregnancies. Further studies are required to determine whether thrombophilias are increased in small-for-gestational -age babies with abnormal umbilical Doppler study results. |
en |
dc.language |
EN |
en |
dc.publisher |
MOSBY, INC |
en |
dc.relation.ispartofseries |
American Journal of Obstetrics and Gynecology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy http://www.sherpa.ac.uk/romeo/issn/0002-9378/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
small for gestational age |
en |
dc.subject |
inherited thrombophilia |
en |
dc.subject |
factor V Leiden |
en |
dc.subject |
prothrombin mutation |
en |
dc.subject |
methylenetetrahydrofolate reductase polymorphism |
en |
dc.subject |
FACTOR-V-LEIDEN |
en |
dc.subject |
VELOCITY WAVE-FORMS |
en |
dc.subject |
METHYLENETETRAHYDROFOLATE REDUCTASE |
en |
dc.subject |
GROWTH-RETARDATION |
en |
dc.subject |
PROTHROMBIN GENE |
en |
dc.subject |
BIRTH-WEIGHT |
en |
dc.subject |
MUTATION |
en |
dc.subject |
DOPPLER |
en |
dc.subject |
WOMEN |
en |
dc.subject |
RESTRICTION |
en |
dc.title |
Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1067/mob.2003.218 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
981 |
en |
pubs.volume |
188 |
en |
dc.rights.holder |
Copyright:
MOSBY, INC |
en |
dc.identifier.pmid |
12712097 |
en |
pubs.end-page |
985 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
5864 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1097-6868 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
12712097 |
en |