Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies

Show simple item record McCowan, Lesley en Craigie, S en Taylor, Rennae en Ward, C en McLintock, C en North, RA en 2014-12-17T02:44:09Z en 2003-04 en
dc.identifier.citation American Journal of Obstetrics and Gynecology, 2003, 188 (4), pp. 981 - 985 en
dc.identifier.issn 0002-9378 en
dc.identifier.uri en
dc.description.abstract OBJECTIVE: The purpose of this study was to determine (1) whether the inherited thrombophilias (the factor V Leiden and prothrombin gene mutations and the methylenetetrahydrofolate reductase [C677T] polymorphism) are increased in women with "idiopathic" (normotensive) small-for-gestational -age pregnancies and/or in their babies and (2) whether fetal carriage of a thrombophilia is associated with abnormal umbilical Doppler studies.STUDY DESIGN: This was a case-controlled study of normotensive women who were delivered of a singleton small-for-gestational-age baby (birth weight, <10th percentile adjusted for sex) with no clinical evidence of chromosomal or congenital abnormality Control subjects were healthy women who were delivered of appropriate-for-gestational-age babies.RESULTS: One hundred forty-five women with small-for-gestational-age,pregnancies and 290 control subjects Were recruited. Small-for-gestational-age babies were born at an earlier gestational age (38 +/- 3.0 weeks) and with a lower birth weight (2373 521 g) than control babies (39.7 +/- 1.3 weeks and 3606 +/- 423 g, P <.01). There were no differences in the rates of factor V Leiden (2.8% vs 3.8%; relative risk, 0.79; 95% Cl, 0.34-1.85), prothrombin gene mutation (2.8% vs 3.1%; relative risk, 0.92; 95% Cl, 0.40-2.09), and methylenetetrahydrofolate reductase C677T polymorphism (13% vs 9%; relative risk, 1.27; 95% Cl, 0.87-1.84) between mothers with small-for-gestational-age babies and control subjects, respectively. Inherited thrombophilias were not increased in small-for-gestational-age babies compared with control babies. Of small-for-gestational-age babies with abnormal umbilical artery Doppler studies (n = 25), 21% had a thrombophilia compared with 11% with normal umbilical artery Doppler studies (n = 68; relative risk, 1.75; 95% Cl, 0.81-3.81).CONCLUSION: The rates of these inherited thrombophilias are not increased in normotensive women with small-for-gestational-age pregnancies. Further studies are required to determine whether thrombophilias are increased in small-for-gestational -age babies with abnormal umbilical Doppler study results. en
dc.language EN en
dc.publisher MOSBY, INC en
dc.relation.ispartofseries American Journal of Obstetrics and Gynecology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject small for gestational age en
dc.subject inherited thrombophilia en
dc.subject factor V Leiden en
dc.subject prothrombin mutation en
dc.subject methylenetetrahydrofolate reductase polymorphism en
dc.subject FACTOR-V-LEIDEN en
dc.subject PROTHROMBIN GENE en
dc.subject BIRTH-WEIGHT en
dc.subject MUTATION en
dc.subject DOPPLER en
dc.subject WOMEN en
dc.subject RESTRICTION en
dc.title Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies en
dc.type Journal Article en
dc.identifier.doi 10.1067/mob.2003.218 en
pubs.issue 4 en
pubs.begin-page 981 en
pubs.volume 188 en
dc.rights.holder Copyright: MOSBY, INC en
dc.identifier.pmid 12712097 en
pubs.end-page 985 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 5864 en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1097-6868 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 12712097 en

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