dc.contributor.author |
Merry, Alan |
en |
dc.contributor.author |
Webster, Craig |
en |
dc.contributor.author |
Holland, RL |
en |
dc.contributor.author |
Middleton, NG |
en |
dc.contributor.author |
Schug, Stephan |
en |
dc.contributor.author |
James, M |
en |
dc.contributor.author |
McGrath, KA |
en |
dc.date.accessioned |
2015-01-06T23:29:07Z |
en |
dc.date.issued |
2004 |
en |
dc.identifier.citation |
Pain, 2004, 111 (3), pp. 313 - 322 |
en |
dc.identifier.issn |
0304-3959 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/23958 |
en |
dc.description.abstract |
We investigated adverse events (AEs) associated with perioperative tenoxicam in a double-blind, prospective, randomised study. Patients undergoing surgery, screened for contraindications to non-steroidal anti-inflammatory drug, received tenoxicam (n=750) on 2843 days or placebo (n=251) on 988 days, in courses of 1–12 days. There was no increase in the overall incidence of side effects with tenoxicam (33 vs 38% with placebo: P=0.15), or in major side effects (3.9 vs 2.0% with placebo: P=0.11). Of major side effects possibly or probably related to tenoxicam (2.1 vs 1.2% with placebo: P=0.26), all but one involved post-operative surgical site bleeding. However, in the subgroup of patients undergoing otorhinolaryngology surgery, surgical site bleeding occurred in 18 of 171 (10.5%) patients on tenoxicam and one of 57 (1.8%) on placebo (P=0.026); of these, nine in the tenoxicam group and 0 in the placebo were classified as major (P=0.07). One patient on tenoxicam experienced endoscopically proven duodenal ulceration with malaena. In conclusion, perioperative tenoxicam is well tolerated in comparison with placebo and the incidence of drug-related major AEs (other than post-operative bleeding) is no greater than 1 in 150 in low risk patients, but in patients undergoing otorhinolaryngological surgery there may be an increased risk of post-operative bleeding. |
en |
dc.relation.ispartofseries |
Pain |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy http://www.sherpa.ac.uk/romeo/issn/0304-3959/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Clinical tolerability of perioperative tenoxicam in 1001 patients - a prospective, controlled, double-blind, multi-centre study |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.pain.2004.07.013 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
313 |
en |
pubs.volume |
111 |
en |
dc.identifier.pmid |
15363875 |
en |
pubs.end-page |
322 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
50929 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Anaesthesiology |
en |
pubs.org-id |
Cent Medical & Hlth Sci Educat |
en |
dc.identifier.eissn |
1872-6623 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
15363875 |
en |