Rongoā: Māori Medicine. A Modern Perspective - Physicochemical Parameters

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dc.contributor.advisor Reynisson, J en
dc.contributor.author Yang, Xue en
dc.date.accessioned 2015-01-07T01:24:45Z en
dc.date.issued 2014 en
dc.identifier.citation 2014 en
dc.identifier.uri http://hdl.handle.net/2292/23968 en
dc.description Full text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Modern drug discovery uses HTS (high throughput screening) to screen compound libraries to find hit compounds. However, it is not easy to design an appropriate screening library. All cultures have used plants for their medicinal properties. In New Zealand, there are diverse and unique flora which potentially offers many unique bioactive compounds. In traditional Māori culture, there was a significant usage of native plants for medicinal purposes. To evaluate if the bioactive compounds can act as leads in modern drug discovery and development, we collected 374 molecules existing in New Zealand indigenous plants from the book New Zealand Medicinal Plants. Their physiochemical properties were evaluated with molecular descriptors using the QikProp software. Results show that nearly half of these compounds lie within drug-like chemical space, and 6.7% of the compounds are lead-like (i.e. they are relatively large). This suggests that the bioactive compounds do have a potential to be used in screening campaigns. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Rongoā: Māori Medicine. A Modern Perspective - Physicochemical Parameters en
dc.type Thesis en
thesis.degree.grantor The University of Auckland en
thesis.degree.level Masters en
dc.rights.holder Copyright: The Author en
pubs.elements-id 471888 en
pubs.record-created-at-source-date 2015-01-07 en


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