dc.contributor.author |
Greene, Carol |
en |
dc.contributor.author |
Chang, CY |
en |
dc.contributor.author |
Fraser, Cameron |
en |
dc.contributor.author |
Nelidova, DE |
en |
dc.contributor.author |
Chen, JA |
en |
dc.contributor.author |
Lim, A |
en |
dc.contributor.author |
Brebner, A |
en |
dc.contributor.author |
McGhee, Jennifer |
en |
dc.contributor.author |
Sherwin, Trevor |
en |
dc.contributor.author |
Green, Colin |
en |
dc.date.accessioned |
2015-01-08T22:39:37Z |
en |
dc.date.issued |
2014-03 |
en |
dc.identifier.citation |
Experimental Cell Research, 2014, 322 (1), pp. 122 - 132 |
en |
dc.identifier.issn |
0014-4827 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/24024 |
en |
dc.description.abstract |
Cells thought to be stem cells isolated from the cornea of the eye have been shown to exhibit neurogenic potential. We set out to uncover the identity and location of these cells within the cornea and to elucidate their neuronal protein and gene expression profile during the process of switching to a neuron-like cell. Here we report that every cell of the adult human and rat corneal stroma is capable of differentiating into a neuron-like cell when treated with neurogenic differentiation specifying growth factors. Furthermore, the expression of genes regulating neurogenesis and mature neuronal structure and function was increased. The switch from a corneal stromal cell to a neuron-like cell was also shown to occur in vivo in intact corneas of living rats. Our results clearly indicate that lineage specifying growth factors can affect changes in the protein and gene expression profiles of adult cells, suggesting that possibly many adult cell populations can be made to switch into another type of mature cell by simply modifying the growth factor environment. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.relation.ispartofseries |
Experimental Cell Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy http://www.sherpa.ac.uk/romeo/issn/0014-4827/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Humans |
en |
dc.subject |
Rats |
en |
dc.subject |
Rats, Wistar |
en |
dc.subject |
Neurons |
en |
dc.subject |
Cells, Cultured |
en |
dc.subject |
Intercellular Signaling Peptides and Proteins |
en |
dc.subject |
Cell Differentiation |
en |
dc.subject |
Adult |
en |
dc.subject |
Cell Transdifferentiation |
en |
dc.subject |
Corneal Stroma |
en |
dc.subject |
Adult Stem Cells |
en |
dc.subject |
Male |
en |
dc.title |
Cells from the adult corneal stroma can be reprogrammed to a neuron-like cell using exogenous growth factors |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.yexcr.2013.12.013 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
122 |
en |
pubs.volume |
322 |
en |
dc.identifier.pmid |
24370575 |
en |
pubs.end-page |
132 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
421608 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1090-2422 |
en |
pubs.record-created-at-source-date |
2015-01-09 |
en |
pubs.dimensions-id |
24370575 |
en |