dc.contributor.author |
James, Joanna |
en |
dc.contributor.editor |
McManus, LM |
en |
dc.contributor.editor |
Mitchell, RN |
en |
dc.date.accessioned |
2015-01-26T23:12:27Z |
en |
dc.date.issued |
2014 |
en |
dc.identifier.citation |
In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Editors: McManus LM, Mitchell RN. 2293-2307. Academic Press, Amsterdam 2014 |
en |
dc.identifier.isbn |
9780123864574 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/24259 |
en |
dc.description.abstract |
Human implantation and early placental development are crucial for on-going pregnancy success, but involve complex interactions between the specialized cells of the placenta (trophoblasts) and the maternal decidua that are not entirely understood. The blastocyst embeds itself within the decidua around 7 days post-fertilization, and the outer trophectoderm layer expands rapidly and differentiates into the specialized trophoblast lineages of the villous placenta. The syncytiotrophoblast covers the surface of the placental villi and is responsible for all nutrient and gas exchange, whereas extravillous trophoblasts grow out from the placenta and invade the decidua to remodel the spiral arteries into wide bore vessels capable of delivering an increased and constant blood supply to the placental surface as pregnancy progresses. This article covers the process of blastocyst implantation, the development of the early human placenta, and the regulation of trophoblast differentiation and invasion at the matern-ofetal interface. |
en |
dc.publisher |
Academic Press |
en |
dc.relation.ispartof |
Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Overview of Human Implantation |
en |
dc.type |
Book Item |
en |
dc.identifier.doi |
10.1016/B978-0-12-386456-7.05005-X |
en |
pubs.begin-page |
2293 |
en |
dc.rights.holder |
Copyright:
Academic Press |
en |
pubs.end-page |
2307 |
en |
pubs.place-of-publication |
Amsterdam |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
411362 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.record-created-at-source-date |
2013-11-27 |
en |