Overview of Human Implantation

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dc.contributor.author James, Joanna en
dc.contributor.editor McManus, LM en
dc.contributor.editor Mitchell, RN en
dc.date.accessioned 2015-01-26T23:12:27Z en
dc.date.issued 2014 en
dc.identifier.citation In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Editors: McManus LM, Mitchell RN. 2293-2307. Academic Press, Amsterdam 2014 en
dc.identifier.isbn 9780123864574 en
dc.identifier.uri http://hdl.handle.net/2292/24259 en
dc.description.abstract Human implantation and early placental development are crucial for on-going pregnancy success, but involve complex interactions between the specialized cells of the placenta (trophoblasts) and the maternal decidua that are not entirely understood. The blastocyst embeds itself within the decidua around 7 days post-fertilization, and the outer trophectoderm layer expands rapidly and differentiates into the specialized trophoblast lineages of the villous placenta. The syncytiotrophoblast covers the surface of the placental villi and is responsible for all nutrient and gas exchange, whereas extravillous trophoblasts grow out from the placenta and invade the decidua to remodel the spiral arteries into wide bore vessels capable of delivering an increased and constant blood supply to the placental surface as pregnancy progresses. This article covers the process of blastocyst implantation, the development of the early human placenta, and the regulation of trophoblast differentiation and invasion at the matern-ofetal interface. en
dc.publisher Academic Press en
dc.relation.ispartof Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Overview of Human Implantation en
dc.type Book Item en
dc.identifier.doi 10.1016/B978-0-12-386456-7.05005-X en
pubs.begin-page 2293 en
dc.rights.holder Copyright: Academic Press en
pubs.end-page 2307 en
pubs.place-of-publication Amsterdam en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 411362 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Obstetrics and Gynaecology en
pubs.record-created-at-source-date 2013-11-27 en

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