Paget's disease in patients of Asian descent in New Zealand.

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Show simple item record Sankaran, S en Naot, Dorit en Grey, Andrew en Cundy, Timothy en 2015-01-27T20:43:09Z en 2012 en
dc.identifier.citation Journal of Bone and Mineral Research, 2012, 27 (1), pp. 223 - 226 en
dc.identifier.issn 0884-0431 en
dc.identifier.uri en
dc.description.abstract Paget's disease is considered to be uncommon in Asian people, but we have noted a recent increase in the number of Asian patients referred to our clinic, on a background of an apparently decreasing prevalence in the population of European descent. In this paper we report clinical and epidemiological features of patients of Asian descent with Paget's disease, referred between 1973 and 2010 to the Auckland Paget's disease clinic. No Asian patients were referred before 1993, but 14 have presented between 1993 and 2010, with a median of eight years between arrival into New Zealand and time of diagnosis. The patients were predominantly of south Asian origin. None of the eight patients tested carried a mutation in exon 8 of the SQSTM1 gene. The number of new Paget's disease referrals expressed as a proportion of the potentially at-risk Asian population in the Auckland region (derived from census data) was 1/10(4) in 2006-2011. Amongst Europeans, the corresponding value decreased from 10/10(4) in 1986-1991 to 2/10(4) in 2006-2010. The increased number of people of Asian descent diagnosed with Paget's disease in the Auckland region has paralleled the increasing size of the local Asian population. The continuing decline of Paget's disease in the European population, in conjunction with the emergence of the disease in the Asian population, supports the view that an environmental determinant to the disease exists and that Asians are not genetically protected. It also implies that the apparent reduction in Paget's disease prevalence in western cities is unlikely to be explicable by the rising Asian population of these cities. en
dc.language ENG en
dc.relation.ispartofseries Journal of Bone and Mineral Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Paget's disease in patients of Asian descent in New Zealand. en
dc.type Journal Article en
dc.identifier.doi 10.1002/jbmr.507 en
pubs.issue 1 en
pubs.begin-page 223 en
pubs.volume 27 en
dc.identifier.pmid 21932347 en en
pubs.end-page 226 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 225728 en Medical and Health Sciences en School of Medicine en Medicine Department en
dc.identifier.eissn 1523-4681 en
pubs.record-created-at-source-date 2012-06-21 en
pubs.dimensions-id 21932347 en

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