Astrocytes and microglia in acute cerebral injury underlying cerebral palsy associated with preterm birth

Show simple item record Mallard, C en Davidson, Joanne en Tan, S en Green, Colin en Bennet, Laura en Robertson, NJ en Gunn, Alistair en 2015-02-03T03:16:09Z en 2014 en
dc.identifier.citation Pediatric Research, 2014, 75 (1-2), pp. 234 - 240 en
dc.identifier.issn 0031-3998 en
dc.identifier.uri en
dc.description.abstract Cerebral palsy is one of the most devastating consequences of brain injury around the time of birth, and nearly a third of cases are now associated with premature birth. Compared with term babies, preterm babies have an increased incidence of complications that may increase the risk of disability, such as intraventricular hemorrhage, periventricular leukomalacia, sepsis, and necrotizing enterocolitis. The response to injury is highly dependent on brain maturity, and although cellular vulnerability is well documented, there is now evidence that premyelinating axons are also particularly sensitive to ischemic injury. In this review, we will explore recent evidence highlighting a central role for glia in mediating increased risk of disability in premature infants, including excessive activation of microglia and opening of astrocytic gap junction hemichannels in spreading injury after brain ischemia, in part likely involving release of adenosine triphosphate (ATP) and overactivation of purinergic receptors, particularly in white matter. We propose the hypothesis that inflammation-induced opening of connexin hemichannels is a key regulating event that initiates a vicious circle of excessive ATP release, which in turn propagates activation of purinergic receptors on microglia and astrocytes. This suggests that developing effective neuroprotective strategies for preterm infants requires a detailed understanding of glial responses. en
dc.publisher International Pediatric Research Foundation, Inc en
dc.relation.ispartofseries Pediatric Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from; en
dc.rights.uri en
dc.title Astrocytes and microglia in acute cerebral injury underlying cerebral palsy associated with preterm birth en
dc.type Journal Article en
dc.identifier.doi 10.1038/pr.2013.188 en
pubs.issue 1-2 en
pubs.begin-page 234 en
pubs.volume 75 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: International Pediatric Research Foundation, Inc en
dc.identifier.pmid 24336433 en
pubs.end-page 240 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.subtype Review en
pubs.elements-id 417485 en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1530-0447 en
pubs.record-created-at-source-date 2013-12-10 en
pubs.dimensions-id 24336433 en

Files in this item

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace