Needle-free jet injection using real-time controlled linear Lorentz-force actuators

Show simple item record Taberner, Andrew en Hogan, NC en Hunter, Ian en 2012-03-08T01:14:23Z en 2015-02-09T04:16:05Z en 2012-11 en
dc.identifier.citation Medical Engineering and Physics, 2012, 34 (9), pp. 1228 - 1235 en
dc.identifier.issn 1350-4533 en
dc.identifier.uri en
dc.description.abstract Needle-free drug delivery by jet injection is achieved by ejecting a liquid drug through a narrow orifice at high pressure, thereby creating a fine high-speed fluid jet that can readily penetrate skin and tissue. Until very recently, all jet injectors utilized force- and pressure-generating principles that progress injection in an uncontrolled manner with limited ability to regulate delivery volume and injection depth. In order to address these shortcomings, we have developed a controllable jet injection device, based on a custom high-stroke linear Lorentz-force motor that is feed-back controlled during the time-course of an injection. Using this device, we are able to monitor and modulate continuously the speed of the drug jet, and regulate precisely the volume of drug delivered during the injection process. We demonstrate our ability to control injection depth (up to 16 mm) and repeatably and precisely inject volumes of up to 250 μL into transparent gels and post-mortem animal tissue. en
dc.relation.ispartofseries Medical Engineering and Physics en
dc.relation.replaces en
dc.relation.replaces 2292/13398 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: en
dc.rights.uri en
dc.subject Drug-delivery en
dc.subject Jet-injection en
dc.subject Needle-free en
dc.subject Real-time control en
dc.subject Lorentz-force motor en
dc.title Needle-free jet injection using real-time controlled linear Lorentz-force actuators en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.medengphy.2011.12.010 en
pubs.issue 9 en
pubs.begin-page 1228 en
pubs.volume 34 en
dc.description.version AM - Accepted Manuscript en
dc.identifier.pmid 22245386 en en
pubs.end-page 1235 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 260942 en Bioengineering Institute en ABI Associates en
pubs.record-created-at-source-date 2011-12-15 en
pubs.dimensions-id 22245386 en

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