Epigenetic and Developmental Basis of Risk of Obesity and Metabolic Disease

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dc.contributor.author Low, Felicia en
dc.contributor.author Gluckman, Peter en
dc.contributor.author Hanson, MA en
dc.contributor.editor Ulloa-Aguirre, A en
dc.contributor.editor Conn, PM en
dc.date.accessioned 2015-03-04T03:04:41Z en
dc.date.issued 2014 en
dc.identifier.citation In Cellular Endocrinology in Health and Disease. Editors: Ulloa-Aguirre A, Conn PM. 111-132. Elsevier Inc., London 2014 en
dc.identifier.isbn 9780124081345 en
dc.identifier.uri http://hdl.handle.net/2292/24742 en
dc.description.abstract The phenomenon whereby an individual’s early life experiences modulate subsequent susceptibility to disease risk is known as the “developmental origins of health and disease” (DOHaD). This chapter focuses on obesity and associated metabolic disease, reviewing this research domain through the lens of an evolutionary developmental biology (evo-devo) conceptual framework. At the molecular level, we use early life nutrition as an illustrative example to review the rapidly accumulating experimental, clinical and epidemiological evidence that epigenetic mechanisms are a key component underlying developmental pathways affecting the risk of obesity and related diseases. Early overnutrition involving evolutionarily novel circumstances such as maternal obesity and gestational diabetes, while potentially representing a non-adaptive pathway to DOHaD, may also be underpinned by epigenetic mechanisms. The evidence that epigenetic dysregulation underlies the pathology of obesity and type 2 diabetes in adults is reviewed, as is the therapeutic potential of developmental epigenomics in improving human health. en
dc.format.extent 23 en
dc.publisher Elsevier Inc. en
dc.relation.ispartof Cellular Endocrinology in Health and Disease en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sciencedirect.com/science/article/pii/B9780124081345000251 en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Epigenetic and Developmental Basis of Risk of Obesity and Metabolic Disease en
dc.type Book Item en
dc.identifier.doi 10.1016/B978-0-12-408134-5.00008-1 en
pubs.begin-page 111 en
dc.rights.holder Copyright: Elsevier Inc. en
pubs.author-url http://www.sciencedirect.com/science/article/pii/B9780124081345000081 en
pubs.end-page 132 en
pubs.place-of-publication London en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 431375 en
pubs.number 8 en
pubs.record-created-at-source-date 2014-04-07 en

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