dc.contributor.author |
Hanson, Mark |
en |
dc.contributor.author |
Low, Felicia |
en |
dc.contributor.author |
Gluckman, Peter |
en |
dc.date.accessioned |
2015-03-04T03:13:32Z |
en |
dc.date.issued |
2011 |
en |
dc.identifier.citation |
Annals of Nutrition and Metabolism, 2011, 58 (Suppl. 2), pp. 8 - 15 |
en |
dc.identifier.issn |
0250-6807 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/24743 |
en |
dc.description.abstract |
Non-communicable diseases (NCDs), such as cardiovascular disease and type 2 diabetes, constitute the main cause of death worldwide. Eighty percent of these deaths occur in low- and middle-income countries, especially as these countries undergo socio-economic improvement following reductions in the burden of infectious disease. The World Health Organization predicts a substantial increase in the incidence of NCDs over the next decade globally. NCDs are generally preventable, but current approaches are clearly inadequate. New initiatives are needed to implement such prevention, and there needs to be greater recognition that early-life interventions are likely to be the most efficacious. Devising appropriate prevention strategies necessitates an understanding of how the developmental environment influences risk. Progress in this field has been slow due to an excessive emphasis on fixed genomic variations (hard inheritance) as the major determinants of disease susceptibility. However, new evidence demonstrates the much greater importance of early-life developmental factors, involving epigenetic processes and ‘soft’ inheritance in modulating an individual’s vulnerability to NCD. This also offers opportunities for novel epigenetic biomarkers of risk or interventions targeting epigenetic pathways to be devised for use in early life. This may pave the way to much more effective, customised interventions to promote health across the life course. |
en |
dc.language |
Eng |
en |
dc.publisher |
Karger |
en |
dc.relation.ispartofseries |
Annals of Nutrition and Metabolism |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0250-6807/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Developmental plasticity |
en |
dc.subject |
Developmental origins of health and disease |
en |
dc.subject |
Epigenetics |
en |
dc.subject |
Gestational diabetes |
en |
dc.subject |
Mismatch |
en |
dc.subject |
Non-communicable diseases |
en |
dc.subject |
Predictive adaptive responses |
en |
dc.subject |
Soft inheritance |
en |
dc.subject |
DEVELOPMENTAL ORIGINS |
en |
dc.subject |
HYPERCALORIC NUTRITION |
en |
dc.subject |
MATERNAL DIET |
en |
dc.subject |
OBESITY |
en |
dc.subject |
DISEASES |
en |
dc.subject |
FETAL |
en |
dc.subject |
LIFE |
en |
dc.subject |
PREGNANCY |
en |
dc.subject |
HEALTH |
en |
dc.subject |
GROWTH |
en |
dc.title |
Epigenetic Epidemiology: The Rebirth of Soft Inheritance |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1159/000328033 |
en |
pubs.issue |
Suppl. 2 |
en |
pubs.begin-page |
8 |
en |
pubs.volume |
58 |
en |
dc.rights.holder |
Copyright:
Karger |
en |
dc.identifier.pmid |
21846977 |
en |
pubs.author-url |
http://www.karger.com/Article/FullText/328033 |
en |
pubs.end-page |
15 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
220074 |
en |
dc.identifier.eissn |
1421-9697 |
en |
pubs.record-created-at-source-date |
2015-03-04 |
en |
pubs.dimensions-id |
21846977 |
en |