Epigenetic Epidemiology: The Rebirth of Soft Inheritance

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dc.contributor.author Hanson, Mark en
dc.contributor.author Low, Felicia en
dc.contributor.author Gluckman, Peter en
dc.date.accessioned 2015-03-04T03:13:32Z en
dc.date.issued 2011 en
dc.identifier.citation Annals of Nutrition and Metabolism, 2011, 58 (Suppl. 2), pp. 8 - 15 en
dc.identifier.issn 0250-6807 en
dc.identifier.uri http://hdl.handle.net/2292/24743 en
dc.description.abstract Non-communicable diseases (NCDs), such as cardiovascular disease and type 2 diabetes, constitute the main cause of death worldwide. Eighty percent of these deaths occur in low- and middle-income countries, especially as these countries undergo socio-economic improvement following reductions in the burden of infectious disease. The World Health Organization predicts a substantial increase in the incidence of NCDs over the next decade globally. NCDs are generally preventable, but current approaches are clearly inadequate. New initiatives are needed to implement such prevention, and there needs to be greater recognition that early-life interventions are likely to be the most efficacious. Devising appropriate prevention strategies necessitates an understanding of how the developmental environment influences risk. Progress in this field has been slow due to an excessive emphasis on fixed genomic variations (hard inheritance) as the major determinants of disease susceptibility. However, new evidence demonstrates the much greater importance of early-life developmental factors, involving epigenetic processes and ‘soft’ inheritance in modulating an individual’s vulnerability to NCD. This also offers opportunities for novel epigenetic biomarkers of risk or interventions targeting epigenetic pathways to be devised for use in early life. This may pave the way to much more effective, customised interventions to promote health across the life course. en
dc.language Eng en
dc.publisher Karger en
dc.relation.ispartofseries Annals of Nutrition and Metabolism en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0250-6807/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Developmental plasticity en
dc.subject Developmental origins of health and disease en
dc.subject Epigenetics en
dc.subject Gestational diabetes en
dc.subject Mismatch en
dc.subject Non-communicable diseases en
dc.subject Predictive adaptive responses en
dc.subject Soft inheritance en
dc.subject MATERNAL DIET en
dc.subject OBESITY en
dc.subject DISEASES en
dc.subject FETAL en
dc.subject LIFE en
dc.subject PREGNANCY en
dc.subject HEALTH en
dc.subject GROWTH en
dc.title Epigenetic Epidemiology: The Rebirth of Soft Inheritance en
dc.type Journal Article en
dc.identifier.doi 10.1159/000328033 en
pubs.issue Suppl. 2 en
pubs.begin-page 8 en
pubs.volume 58 en
dc.rights.holder Copyright: Karger en
dc.identifier.pmid 21846977 en
pubs.author-url http://www.karger.com/Article/FullText/328033 en
pubs.end-page 15 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 220074 en
dc.identifier.eissn 1421-9697 en
pubs.record-created-at-source-date 2015-03-04 en
pubs.dimensions-id 21846977 en

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