Developmental Plasticity, Epigenetics and Human Health

Show simple item record Low, Felicia en Gluckman, PD en Hanson, MA en 2015-03-04T03:37:52Z en 2012 en
dc.identifier.citation Evolutionary Biology, 2012, 39 (4), pp. 650 - 665 en
dc.identifier.issn 0071-3260 en
dc.identifier.uri en
dc.description.abstract The unrelenting rise in global rates of non-communicable disease has necessitated a thorough re-evaluation of the current use of adult- and lifestyle-based strategies to curb the growing epidemic. There is a rapidly emerging set of epidemiological, experimental and clinical data suggesting that developmental factors play a considerable role in determining individual disease risk later in life. This phenomenon is known as the Developmental Origins of Health and Disease (DOHaD). Developmental factors, such as maternal and paternal nutrition, gestational diabetes mellitus, and even the normative range of developmental experiences, may evoke the processes of developmental plasticity which enable an organism to change its developmental trajectory in response to environmental cues. However in the event of a mismatch between the early and mature environment, such anticipatory responses may become maladaptive and lead to elevated risk of disease. The evo-devo and eco-evo-devo framework for DOHaD has more recently been supported by mechanistic insights enabled by rapid advances in epigenetic research. Increasing evidence suggests that developmental plasticity may be effected by epigenetically mediated modulation of the expression of specific genes. These mechanisms include DNA methylation, histone modifications and noncoding RNA activity. A growing number of animal studies also point towards the transgenerational inheritance of epigenetic marks, which may have implications for the perpetuation of ill-health. However early-life epigenotyping may find utility as a prognostic marker of metabolic dysfunction for identification and treatment of at-risk individuals. en
dc.publisher Springer en
dc.relation.ispartofseries Evolutionary Biology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Developmental Plasticity, Epigenetics and Human Health en
dc.type Journal Article en
dc.identifier.doi 10.1007/s11692-011-9157-0 en
pubs.issue 4 en
pubs.begin-page 650 en
pubs.volume 39 en
dc.rights.holder Copyright: Springer en
pubs.end-page 665 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 263132 en
dc.identifier.eissn 1934-2845 en
pubs.record-created-at-source-date 2011-12-19 en

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