Kölliker's Organ and the Development of Spontaneous Activity in the Auditory System: Implications for Hearing Dysfunction

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dc.contributor.author Dayaratne, Manikku en
dc.contributor.author Vlajkovic, Srdjan en
dc.contributor.author Lipski, Janusz en
dc.contributor.author Thorne, Peter en
dc.date.accessioned 2015-03-12T00:59:08Z en
dc.date.issued 2014 en
dc.identifier.citation BioMed Research International, 2014, Article ID 367939, 8 pages en
dc.identifier.issn 2314-6133 en
dc.identifier.uri http://hdl.handle.net/2292/24826 en
dc.description.abstract Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity involves a group of columnar epithelial supporting cells forming Kölliker's organ, which is only present during this critical period of auditory development. There is strong evidence for a purinergic signalling mechanism underlying such activity. ATP released through connexin hemichannels may activate P2 purinergic receptors in both Kölliker's organ and the adjacent IHCs, leading to generation of electrical activity throughout the auditory system. However, recent work has suggested an alternative origin, by demonstrating the ability of IHCs to generate this spontaneous activity without activation by ATP. Regardless, developmental abnormalities of Kölliker's organ may lead to congenital hearing loss, considering that mutations in ion channels (hemichannels, gap junctions, and calcium channels) involved in Kölliker's organ activity share strong links with such types of deafness. en
dc.format.medium Print-Electronic en
dc.language Eng en
dc.relation.ispartofseries BioMed Research International en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2314-6133/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Kölliker's Organ and the Development of Spontaneous Activity in the Auditory System: Implications for Hearing Dysfunction en
dc.type Journal Article en
dc.identifier.doi 10.1155/2014/367939 en
pubs.issue 367939 en
pubs.volume 2014 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 25210710 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 456532 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Physiology Division en
pubs.org-id Population Health en
pubs.org-id Audiology en
dc.identifier.eissn 2314-6141 en
pubs.record-created-at-source-date 2015-03-12 en
pubs.dimensions-id 25210710 en

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