dc.contributor.author |
Vlajkovic, Srdjan |
en |
dc.contributor.author |
Chang, H |
en |
dc.contributor.author |
Paek, SY |
en |
dc.contributor.author |
Chi, HH-T |
en |
dc.contributor.author |
Sreebhavan, S |
en |
dc.contributor.author |
Telang, Ravindra |
en |
dc.contributor.author |
Tingle, Malcolm |
en |
dc.contributor.author |
Housley, GD |
en |
dc.contributor.author |
Thorne, Peter |
en |
dc.date.accessioned |
2015-03-12T01:19:42Z |
en |
dc.date.issued |
2014 |
en |
dc.identifier.citation |
BioMed Research International, 2014, Article ID 841489, 10 pages |
en |
dc.identifier.issn |
2314-6133 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/24827 |
en |
dc.description.abstract |
We have previously shown that adenosine amine congener (ADAC), a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury. Here we demonstrate the dose-dependent rescue effects of ADAC on noise-induced cochlear injury in a rat model and establish the time window for treatment. METHODS: ADAC (25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration. RESULTS: ADAC was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products. CONCLUSION: Our data show that ADAC mitigates noise-induced hearing loss in a dose- and time-dependent manner, but further studies are required to establish its translation as a clinical otological treatment. |
en |
dc.relation.ispartofseries |
BioMed Research International |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2314-6133/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by/3.0/ |
en |
dc.title |
Adenosine Amine Congener as a Cochlear Rescue Agent |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1155/2014/841489 |
en |
pubs.issue |
841489 |
en |
pubs.volume |
2014 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
25243188 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/OpenAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
413371 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Physiology Division |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Audiology |
en |
dc.identifier.eissn |
2314-6141 |
en |
pubs.record-created-at-source-date |
2014-11-20 |
en |
pubs.dimensions-id |
25243188 |
en |