A Comparative Study between Rats and Pigeons and their Mitochondrial Reactive Oxygen Species Production and Tolerance to the Reactive Oxygen Species

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dc.contributor.advisor Hickey, A en
dc.contributor.advisor Hedges, C en
dc.contributor.author Khan, Hanin en
dc.date.accessioned 2015-03-13T02:07:53Z en
dc.date.issued 2015 en
dc.identifier.citation 2015 en
dc.identifier.uri http://hdl.handle.net/2292/24842 en
dc.description Full text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Aging differences between pigeons and rats have been related to a number of factors which include the production of Reactive Oxygen Species (ROS), sensitivity to inhibition caused by ROS (oxidative stress) and length of telomeres. The Maximum Lifespan Potential (MSLP) for a pigeon is 35 years where as a rat of the same mass has a MSLP of 5 years. There is evidence that elevated levels of oxidative stress impacts the MSLP of an animal. There have been studies in the past which show rats producing larger volumes of ROS and pigeons produce lower volumes. Those studies however, did not replicate conditions found in vivo, this project was carried out to mimic those conditions including physiological temperature, keeping tissues intact (not isolating the mitochondria), and using a range of substrates and inhibitors. The results produced by examining the samples under these conditions, challenge the findings of previous studies. Results show that pigeons produce more ROS in general compared with rats and are also more sensitive to inhibition by Hydrogen Peroxide (H2O2). There is also evidence that suggests increased oxidative stress and lowered glucose levels also increases MSLP of an animal and this agrees with the results found in this project. It is speculated that a larger ROS production is the reason why birds such as the pigeon, live so much longer than mammals of the same mass. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ en
dc.title A Comparative Study between Rats and Pigeons and their Mitochondrial Reactive Oxygen Species Production and Tolerance to the Reactive Oxygen Species en
dc.type Thesis en
thesis.degree.grantor The University of Auckland en
thesis.degree.level Masters en
dc.rights.holder Copyright: The Author en
pubs.elements-id 478190 en
pubs.record-created-at-source-date 2015-03-13 en


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