Battle of the hemichannels -- Connexins and Pannexins in ischemic brain injury

Show simple item record Davidson, Joanne en Green, Colin en Bennet, Laura en Gunn, Alistair en 2015-05-15T05:38:09Z en 2015-10 en
dc.identifier.citation International Journal of Developmental Neuroscience 45:66-74 2015 en
dc.identifier.issn 0736-5748 en
dc.identifier.uri en
dc.description.abstract Perinatal ischemic brain injury can occur as a result of a global ischemic insult or focal ischemic stroke in the preterm or full-term neonate. One of the most striking features of HI injury is that, after initial recovery of cellular oxidative metabolism, there is a delayed, 'secondary' mitochondrial failure that spreads over time from the most severely damaged areas outwards, into previously undamaged regions. This secondary failure is accompanied by transient seizure activity and cytotoxic edema. The specific mechanisms of this spread are poorly understood, but it is at least partly associated with spreading waves of depression that can trigger cell death in neighboring uninjured tissues. Both Connexin and Pannexin hemichannels may mediate release of paracrine molecules that in turn propagate cell death messages by releasing intracellular mediators, such as ATP, NAD(+), or glutamate or by abnormally prolonged opening to allow cell edema. This review will discuss the controversy around the relative contribution of both Connexin and Pannexin hemichannels and mechanisms by which they may contribute to the spread of ischemic brain injury. en
dc.description.uri en
dc.language ENG en
dc.relation.ispartofseries International Journal of Developmental Neuroscience en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.subject Cerebral ischemia en
dc.subject Connexin 43 en
dc.subject Fetal sheep en
dc.subject Hemichannel en
dc.subject Neuroprotection en
dc.subject Pannexin en
dc.title Battle of the hemichannels -- Connexins and Pannexins in ischemic brain injury en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ijdevneu.2014.12.007 en
pubs.begin-page 66 en
pubs.volume 45 en
dc.description.version AM - Accepted Manuscript en
dc.identifier.pmid 25546019 en en
pubs.end-page 74 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.subtype Review en
pubs.elements-id 471543 en Medical and Health Sciences en Medical Sciences en Physiology Division en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1873-474X en
dc.identifier.pii S0736-5748(14)00209-3 en
pubs.record-created-at-source-date 2015-01-03 en
pubs.dimensions-id 25546019 en

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