Abstract:
Clinical Question What treatments are associated with improved outcomes for women with endometriosis? Bottom Line The levonorgestrel-releasing intrauterine system (LNG-IUD), gonadotropin-releasing hormone analogues (GnRHa; nafarelin, leuprolide, buserelin, goserelin, triptorelin), laparoscopic ablation, and excision are associated with relief of pain due to endometriosis. Gonadotropin-releasing hormone analogues and laparoscopic ablation or excision are associated with increased clinical pregnancy rates in women with endometriosis. Gonadotropin-releasing hormone analogues, danazol, and depot progestagens are associated with a higher incidence of adverse events. Endometriosis is a common gynecological condition characterized by deposits of endometrial tissue outside the endometrial cavity, such as the liver, diaphragm, umbilicus, and pleural cavity.1 The prevalence is as high as 10% in the general population and as high as 40% in subfertile women.2 Pain is the common presenting feature and often recurs, even after treatment.3 This JAMA Clinical Evidence Synopsis summarizes a Cochrane review1 to assess treatments that are associated with improved outcomes for women with endometriosis