The Preparation of High-content Gemcitabine pH Sensitive Liposomes and Evaluation of their Cytotoxicity to Drug Resistant Pancreatic Cancer Cells

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dc.contributor.author Xu, Hongtao en
dc.contributor.author Paxton, James en
dc.contributor.author Li, Y en
dc.contributor.author Wu, Zimei en
dc.coverage.spatial Chicago en
dc.date.accessioned 2015-06-12T03:25:54Z en
dc.date.issued 2014-07-14 en
dc.identifier.citation Controlled Release Society Annual Meeting 2014, Chicago, 13 Jul 2014 - 16 Jul 2014. 14 Jul 2014 en
dc.identifier.uri http://hdl.handle.net/2292/25871 en
dc.description.abstract Gemcitabine containing pH sensitive liposomes (PSL) has been prepared using a Small Volume Incubation (SVI) method. The entrapment efficiency (EE) and drug loading (DL) were 29.5 ± 0.2% and 4.2 ± 0.2%, a respective 7- and 70-fold increase compared to the thin film hydration extrusion (TFHE) method. The particle size and zeta potential were 146 ± 2 nm and -26.4 ± 2.0 mV. The gemcitabine PSL showed significantly enhanced cytotoxicity than free gemcitabine solution and gemcitabine non-pH-sensitive liposomes (NPSL) to pancreatic cancer cells. en
dc.relation.ispartof Controlled Release Society Annual Meeting 2014 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title The Preparation of High-content Gemcitabine pH Sensitive Liposomes and Evaluation of their Cytotoxicity to Drug Resistant Pancreatic Cancer Cells en
dc.type Conference Item en
pubs.author-url http://www.controlledreleasesociety.org/meetings/Archives/2014AnnualMeeting/abstracts/Pages/2014Abstracts.aspx en
pubs.finish-date 2014-07-16 en
pubs.start-date 2014-07-13 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Abstract en
pubs.elements-id 473896 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2015-01-27 en


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