Role of Fiber Orientation in Atrial Arrythmogenesis

Show simple item record Kharche, S en Castro, S en Thomas, B en Colman, M en Jarvis, J en Smaill, Bruce en Zhang, H en Stevenson, R en Zhao, Jichao en
dc.coverage.spatial Cambridge, Massachusetts en 2015-06-23T01:32:22Z en 2014 en
dc.identifier.citation Computing in Cardiology 41st Annual Conference (CinC), Cambridge, Massachusetts, 07 Sep 2014 - 10 Sep 2014. 41: 1041-1044. 2014 en
dc.identifier.issn 2325-8861 en
dc.identifier.uri en
dc.description.abstract Background: Electrical wave-front propagation in the atria is determined by local fiber orientation. Atrial fibrillation (AF) progresses with enhanced anisotropy. We illustrate AF due to myofiber structure. Methods: A 3D rabbit atrial anatomical model at 20 µm resolution with realistic fiber orientation was constructed based on contrast-enhanced micro-CT imaging. The Fenton-Karma excitation cell model was adapted to reproduce rabbit atrial action potential period (APD) of 80 ms. Diffusivities were estimated for longitudinal (Dp = 0.0065 mm2 /ms for CV = 0.5 mm/ms) and transverse directions (Dp = 0.06 mm2 /ms for CV = 0.15 mm/ms) of the fiber orientation. The estimated diffusion constants were deployed in the 3D anisotropic atrial model (Figure) where pacing was conducted with a reducing S2 interval to facilitate initiation of atrial arrhythmia. Multiple simulations were conducted with varying values of diffusion anisotropy and stimulus locations to evaluate the role of anisotropy to evaluate propensity to initiate arrhythmia. BeatBox, a cardiac simulation package, was used throughout this work. Results: Under physiological anisotropy conditions, a rapid right atrial activation was followed by the left atrial activation. Excitation waves reached the AV border where they terminated. Upon reduction of conduction heterogeneity, re-entry was initiated by the rapid pacing and the activation of both atrial chambers was almost simultaneous. Conclusions: Myofiber orientation is an effective mechanism for regulating atrial activation. Modification of its myo-architecture is proarrhythmic. en
dc.relation.ispartof Computing in Cardiology 41st Annual Conference (CinC) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Role of Fiber Orientation in Atrial Arrythmogenesis en
dc.type Conference Item en
pubs.begin-page 1041 en
pubs.volume 41 en
pubs.end-page 1044 en
pubs.finish-date 2014-09-10 en
pubs.start-date 2014-09-07 en
dc.rights.accessrights en
pubs.subtype Proceedings en
pubs.elements-id 477288 en Bioengineering Institute en ABI Associates en
pubs.record-created-at-source-date 2015-03-15 en

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