Corticomotor excitability and plasticity following complex visuomotor training in young and old adults

Show simple item record Cirillo, John en Todd, G en Semmler, JG en 2015-06-24T03:00:08Z en 2011-12 en
dc.identifier.citation European Journal of Neuroscience, 2011, 34 (11), pp. 1847 - 1856 en
dc.identifier.issn 0953-816X en
dc.identifier.uri en
dc.description.abstract Previous studies with transcranial magnetic stimulation (TMS) have shown that advancing age may influence plasticity induction in human motor cortex (M1), but these changes have been assessed with TMS-induced paradigms or simple motor tasks. The aim of this study was to examine changes in corticospinal excitability and intracortical inhibition as markers of corticomotor plasticity following complex motor training in young and old adults. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 16 young (20–35 years) and 16 older (aged 60–75 years) adults before and after motor skill training. Motor training consisted of three 6-minute blocks of a complex visuomotor task that required matching the metacarpophalangeal (MCP) joint angle of the index finger using abduction–adduction movements. Single- and paired-pulse TMS over the left M1 was used to assess changes in right FDI motor-evoked potentials (MEPs) and short-interval intracortical inhibition (SICI) before and after each training block. Visuomotor tracking performance was diminished in old compared with young adults throughout training. However, improvement in tracking error was similar for young and old adults (7–24% increase in each training block). For young and old adults, motor training increased FDI MEP amplitude (≥ 20%) and reduced the magnitude of SICI (≥ 19%) after each visuomotor training block, reflecting use-dependent plasticity. However, no difference in corticomotor plasticity (change in MEP or SICI) was observed between young and old adults. Further studies are needed to identify the experimental or behavioral factors that might contribute to the maintenance of corticomotor plasticity in older adults. en
dc.relation.ispartofseries European Journal of Neuroscience en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Corticomotor excitability and plasticity following complex visuomotor training in young and old adults en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1460-9568.2011.07870.x en
pubs.issue 11 en
pubs.begin-page 1847 en
pubs.volume 34 en
dc.identifier.pmid 22004476 en
pubs.end-page 1856 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 478252 en Science en Exercise Sciences en
pubs.record-created-at-source-date 2015-06-24 en
pubs.dimensions-id 22004476 en

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