Hemispheric differences in use-dependent corticomotor plasticity in young and old adults

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dc.contributor.author Cirillo, John en
dc.contributor.author Rogasch, NC en
dc.contributor.author Semmler, JG en
dc.date.accessioned 2015-06-24T03:46:58Z en
dc.date.issued 2010-08 en
dc.identifier.citation Experimental Brain Research, 2010, 205 (1), pp. 57 - 68 en
dc.identifier.issn 0014-4819 en
dc.identifier.uri http://hdl.handle.net/2292/26014 en
dc.description.abstract The aim of this study was to examine corticomotor excitability and plasticity following repetitive thumb abduction training in left and right hands of young and old adults. Electromyographic recordings were obtained from the abductor pollicis brevis (APB) muscle of 12 young (aged 18–27 years) and 14 old (aged 63–75 years) adults. Motor training consisted of 300 ballistic abductions of the thumb to maximize peak abduction acceleration, with each hand tested in a separate session. Transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) was used to assess changes in contralateral APB motor-evoked potentials (MEPs) and short-interval intracortical inhibition (SICI) before and after training. For young and old adults, APB MEP amplitude increased for both hands after training, which is indicative of use-dependent plasticity. However, the increase in MEP amplitude was 21% (P = 0.04) greater in the left (non-dominant) hand compared with the right (dominant) hand. This occurred despite a 40% greater improvement in peak thumb abduction acceleration (motor learning) for the right hand in young subjects compared with the left hand in young subjects (P < 0.04) and the right hand in old subjects (P < 0.01). Furthermore, no difference in use-dependent plasticity was observed between young and old adults, and SICI remained unchanged following ballistic training for both hands in all subjects. These findings suggest that there is greater strengthening of corticomotor circuits for control of the left compared with the right hand during simple ballistic thumb training and that an age-related decline in motor learning was observed only in the dominant hand. In contrast to previous studies, these data also indicate that young and old adults can demonstrate similar use-dependent corticomotor plasticity during this simple thumb-training task. en
dc.relation.ispartofseries Experimental Brain Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0014-4819/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Hemispheric differences in use-dependent corticomotor plasticity in young and old adults en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00221-010-2332-1 en
pubs.issue 1 en
pubs.begin-page 57 en
pubs.volume 205 en
dc.identifier.pmid 20574685 en
pubs.end-page 68 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 478253 en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1432-1106 en
pubs.record-created-at-source-date 2015-06-24 en
pubs.dimensions-id 20574685 en


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