Acute effects of triterpene compounds on locomotor performance and Morris water maze tasks in Spraque-Dawley rats

Show simple item record Nasir, MN en Habsah, M en Adzim, MKR en Norhayati, AH en Muralidhara, DV en Zubaidi, AL en 2015-06-24T04:58:52Z en 2015 en
dc.identifier.citation Biomedical Research, 2015, 26 (2), pp. 304 - 310 (6) en
dc.identifier.issn 0970-938X en
dc.identifier.uri en
dc.description.abstract Centella asiatica has been recognized as one of the plants that can be used to surge cognitive function in animals and humans. Currently, several compounds isolated from C. asiatica have been proven to enhance cognitive function via learning and memory properties. The present study investigated the acute effects of administration of triterpene compounds isolated from C. asiatica on memory and learning in male Spraque-Dawley rats via Morris water maze and their influences on motor activity in locomotor performance. The five-week old Spraque-Dawley rats were intraperitoneally administered with 10 mg/kg concentration of triterpene compounds; asiatic acid, madecassic acid, madecassoside and the control groups with scopolamine and saline. The rats were then evaluated via Morris water maze tasks and locomotor activity. The administration of 10 mg/kg of asiatic acid resulted in significantly improved memory (p<0.5) with increased escaped latency compared to saline and scopolamine. Furthermore, the administration of 10 mg/kg of madecassic acid and madecassoside significantly induced higher escape latency compared to scopolamine (p<0.5) but there was no significant difference compared to saline (p<0.5). For spontaneous locomotor activity, the three triterpene compounds showed no effect on locomotor activity as compared to saline group. However, the triterpene compounds had significant effect on locomotor activity as compared to scopolamine group (p<0.5). The administration of acute asiatic acid facilitated escaped latency which can be translated as having the properties of enhancement on memory and learning. Hence, it may serve to be useful on improving memory and learning with no sedative effect on the locomotor performance. en
dc.relation.ispartofseries Biomedical Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Acute effects of triterpene compounds on locomotor performance and Morris water maze tasks in Spraque-Dawley rats en
dc.type Journal Article en
pubs.issue 2 en
pubs.begin-page 304 en
pubs.volume 26 en en
pubs.end-page 310 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 478259 en Academic Services en Examinations en
pubs.record-created-at-source-date 2015-03-16 en

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