Motor cortex plasticity induced by paired associative stimulation is enhanced in physically active individuals

Show simple item record Cirillo, John en Lavender, AP en Ridding, MC en Semmler, JG en 2015-06-25T23:48:28Z en 2009-12 en
dc.identifier.citation The Journal of Physiology, 2009, 587 (24), pp. 5831 - 5842 (12) en
dc.identifier.issn 0022-3751 en
dc.identifier.uri en
dc.description.abstract Recent evidence indicates that regular physical activity enhances brain plasticity (i.e. the ability to reorganise neural connections) and improves neurocognitive function. However, the effect of regular physical activity on human motor cortex function is unknown. The purpose of this study was to examine motor cortex plasticity for a small hand muscle in highly active and sedentary individuals. Electromyographic recordings were obtained from the left abductor pollicis brevis (APB) muscle of 14 active and 14 sedentary subjects (aged 18–38 yrs). The extent of physical activity was assessed by questionnaire, where the physically active subjects performed >150 min per day moderate-to-vigorous aerobic activity on at least 5 days per week, whereas the sedentary group performed <20 min per day of physical activity on no more than 3 days per week. Transcranial magnetic stimulation (TMS) of the right hemisphere was used to assess changes in APB motor-evoked potentials (MEPs), input–output curve (IO curve), short-interval intracortical inhibition (SICI) and cortical silent period (CSP). Neuroplastic changes were induced using paired-associative stimulation (PAS), which consisted of 90 paired stimuli (0.05 Hz for 30 min) of median nerve electrical stimulation at the wrist followed 25 ms later by TMS to the hand area of motor cortex. The IO curve slope was 35% steeper in individuals with increased physical activity (combined before and after PAS, P < 0.05), suggesting increased motor cortex excitability, although there was no difference in SICI or CSP between groups. PAS induced an increase in MEP amplitude in the physically active subjects (54% increase compared with before, P < 0.01), but no significant facilitation in the sedentary subjects. We conclude that participation in regular physical activity may offer global benefits to motor cortex function that enhances neuroplasticity, which could improve motor learning and neurorehabilitation in physically active individuals. en
dc.language English en
dc.publisher Wiley-Blackwell / The Physiological Society en
dc.relation.ispartofseries The Journal of Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Motor cortex plasticity induced by paired associative stimulation is enhanced in physically active individuals en
dc.type Journal Article en
dc.identifier.doi 10.1113/jphysiol.2009.181834 en
pubs.issue 24 en
pubs.begin-page 5831 en
pubs.volume 587 en
dc.rights.holder Copyright: Wiley-Blackwell / The Physiological Society en
dc.identifier.pmid 19858227 en en
pubs.end-page 5842 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 478254 en Science en Exercise Sciences en
dc.identifier.eissn 1469-7793 en
pubs.record-created-at-source-date 2015-06-26 en
pubs.dimensions-id 19858227 en

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