Estradiol alters the chemosensitive cardiac afferent reflex in female rats by augmenting sympathoinhibition and attenuating sympathoexcitation

Show simple item record Pinkham, Maximilian en Barrett, Carolyn en 2015-07-06T22:28:11Z en 2015-03-19 en 2015-06 en
dc.identifier.citation Clinical and Experimental Pharmacology and Physiology, 2015, 42 (6), pp. 622 - 631 en
dc.identifier.issn 0305-1870 en
dc.identifier.uri en
dc.description.abstract The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were performed in anaesthetized, sinoaortic baroreceptor denervated male, female and ovariectomized female (OVX) Wistar rats with either intact cardiac innervation or bilateral vagotomy. To investigate the chemosensitive cardiac afferent reflexes renal SNA, heart rate (HR) and arterial pressure (AP) were recorded before and following application of capsaicin onto the epicardial surface of the left ventricle. Compared to males, ovary-intact females displayed similar cardiac afferent reflex mediated changes in renal SNA albeit with a reduced maximum sympathetic reflex driven increase in renal SNA. In females, ovariectomy significantly attenuated the cardiac vagal afferent reflex mediated inhibition of renal SNA (renal SNA decreased 2 ± 17% in OVX versus -50 ± 4% in ovary-intact females, P < 0.05) and augmented cardiac sympathetic afferent reflex mediated sympathoexcitation (renal SNA increased 91 ± 11% in OVX vs 62 ± 9% in ovary-intact females, P < 0.05) so that overall increases in reflex driven sympathoexcitation were significantly enhanced. Chronic estradiol replacement, but not progesterone replacement, begun at time of ovariectomy restored cardiac afferent reflex responses to be similar as ovary-intact females. Vagal denervation eliminated all group differences. The current findings show ovariectomy in female rats, mimicking menopause in women, results in greater chemosensitive cardiac afferent reflex driven sympathoexcitation and does so, at least partly, via the loss of estradiols actions on the cardiac vagal afferent reflex pathway. en
dc.format.medium Print en
dc.language English en
dc.publisher Wiley en
dc.relation.ispartofseries Clinical and Experimental Pharmacology and Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Estradiol alters the chemosensitive cardiac afferent reflex in female rats by augmenting sympathoinhibition and attenuating sympathoexcitation en
dc.type Journal Article en
dc.identifier.doi 10.1111/1440-1681.12392 en
pubs.issue 6 en
pubs.begin-page 622 en
pubs.volume 42 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: Wiley en
dc.identifier.pmid 25810130 en en
pubs.end-page 631 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.subtype Article en
pubs.elements-id 479386 en Medical and Health Sciences en Medical Sciences en Physiology Division en
dc.identifier.eissn 1440-1681 en
pubs.record-created-at-source-date 2015-07-07 en
pubs.dimensions-id 25810130 en

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