Necrotic trophoblast debris increases blood pressure during pregnancy

Show simple item record Lau, Sien en Barrett, Carolyn en Guild, Sarah-Jane en Chamley, Lawrence en
dc.coverage.spatial Ireland en 2015-07-09T02:32:22Z en 2012-12-13 en 2013-04 en
dc.identifier.citation Journal of Reproductive Immunology, 2013, 97 (2), pp. 175 - 182 en
dc.identifier.issn 0165-0378 en
dc.identifier.uri en
dc.description.abstract Preeclampsia is a major disease of human pregnancy characterised by hypertension and proteinuria. These signs are preceded by systemic maternal endothelial dysfunction. Hypertension in preeclampsia appears to be triggered by a placental factor, which leads to endothelial activation/dysfunction. One potential placental trigger for preeclampsia is necrotic trophoblast cell debris shed from the placenta into maternal blood. The larger trophoblast debris is trapped in the maternal pulmonary vessels and is hypothesised to be cleared by endothelial cells. Phagocytosis of necrotic but not apoptotic trophoblast debris by endothelial cells leads to their activation in vitro. We hypothesised that intravenous injection of necrotic trophoblast debris would induce hypertension in pregnant rats. Virgin female Wistar rats were surgically implanted with telemetry devices to monitor arterial blood pressure and chronic intravenous catheters to allow delivery of necrotic trophoblast debris. After recovery, the rats were mated and, from day 6 of gestation until parturition, they were given five consecutive daily injections per week of 5×10(6) necrotic Jeg-3 cells per kilo bodyweight. Control rats received vehicle injections. The normalised mean arterial blood pressure of rats receiving injections of necrotic trophoblast debris was higher than control rats during the third week of gestation, while mean arterial blood pressure decreased less from the pre-pregnancy baseline compared to control rats. These results suggest that necrotic trophoblast debris has a hypertensive effect which manifests in late gestation in Wistar rats and supports the theory that necrotic trophoblast debris may trigger the symptoms of preeclampsia. en
dc.description.uri en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Journal of Reproductive Immunology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Necrotic en
dc.subject Trophoblast deportation en
dc.subject Trophoblast debris en
dc.subject Pre-Eclampsia en
dc.subject Hypertension en
dc.subject Blood pressure en
dc.subject Pregnancy en
dc.subject Animals en
dc.subject Arterial Pressure en
dc.subject Cells, Cultured en
dc.subject Endothelial Cells en
dc.subject Female en
dc.subject Heart Rate en
dc.subject Placenta en
dc.subject Proteinuria en
dc.subject Rats en
dc.subject Rats, Wistar en
dc.subject Trophoblasts en
dc.title Necrotic trophoblast debris increases blood pressure during pregnancy en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jri.2012.12.005 en
pubs.issue 2 en
pubs.begin-page 175 en
pubs.volume 97 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 23485144 en en
pubs.end-page 182 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Journal Article en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Article en
pubs.elements-id 373903 en Medical and Health Sciences en Medical Sciences en Physiology Division en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1872-7603 en
dc.identifier.pii S0165-0378(13)00012-0 en
pubs.record-created-at-source-date 2015-07-09 en
pubs.dimensions-id 23485144 en

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