Ipsilateral motor pathways after stroke: implications for non-invasive brain stimulation

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dc.contributor.author Bradnam, Lynley en
dc.contributor.author Stinear, Cathy en
dc.contributor.author Byblow, Winston en
dc.coverage.spatial Switzerland en
dc.date.accessioned 2015-07-16T00:11:09Z en
dc.date.issued 2013 en
dc.identifier.citation Frontiers in Human Neuroscience, 2013, 7, Article number 184 en
dc.identifier.uri http://hdl.handle.net/2292/26272 en
dc.description.abstract In humans the two cerebral hemispheres have essential roles in controlling the upper limb. The purpose of this article is to draw attention to the potential importance of ipsilateral descending pathways for functional recovery after stroke, and the use of non-invasive brain stimulation (NBS) protocols of the contralesional primary motor cortex (M1). Conventionally NBS is used to suppress contralesional M1, and to attenuate transcallosal inhibition onto the ipsilesional M1. There has been little consideration of the fact that contralesional M1 suppression may also reduce excitability of ipsilateral descending pathways that may be important for paretic upper limb control for some patients. One such ipsilateral pathway is the cortico-reticulo-propriospinal pathway (CRPP). In this review we outline a neurophysiological model to explain how contralesional M1 may gain control of the paretic arm via the CRPP. We conclude that the relative importance of the CRPP for motor control in individual patients must be considered before using NBS to suppress contralesional M1. Neurophysiological, neuroimaging, and clinical assessments can assist this decision making and facilitate the translation of NBS into the clinical setting. en
dc.language eng en
dc.relation.ispartofseries Frontiers in Human Neuroscience en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.frontiersin.org/Copyright.aspx http://www.sherpa.ac.uk/romeo/issn/1662-5161/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject propriospinal en
dc.subject rehabilitation en
dc.subject stroke en
dc.subject transcranial direct current stimulation en
dc.subject upper limb en
dc.title Ipsilateral motor pathways after stroke: implications for non-invasive brain stimulation en
dc.type Journal Article en
dc.identifier.doi 10.3389/fnhum.2013.00184 en
pubs.volume 7 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 23658541 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Journal Article en
pubs.subtype Article en
pubs.elements-id 379950 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1662-5161 en
pubs.number 184 en
pubs.record-created-at-source-date 2015-07-16 en
pubs.dimensions-id 23658541 en

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