Retention on anti-tumour necrosis factor therapy: the Waikato experience

Show simple item record Ip, K en Hartley, L en Solanki, K en White, Douglas en 2015-07-20T00:04:24Z en 2015-05-29 en
dc.identifier.citation New Zealand Medical Journal, 2015, 128 (1415), pp. 34 - 40 en
dc.identifier.issn 1175-8716 en
dc.identifier.uri en
dc.description.abstract AIM: To investigate the retention on anti-TNF agents used in a real-world setting, and determine the factors predicting retention on drug. METHOD: Patients starting anti-TNF therapy were recorded prospectively on the departmental database. Medical records of all patients commenced on anti-TNF therapy between 2006 and 2013 at the Rheumatology Department, Waikato Hospital, Hamilton, were retrospectively reviewed to obtain details of their course on biologic therapy. RESULTS: 183 patients were identified. 139 (76.5%) were commenced on adalimumab. The predominant indication was rheumatoid arthritis (52.5%). 60 patients (32.8%) discontinued their initial anti-TNF agent. Of these, 31.7% were due to primary failure, 36.7% due to secondary failure and 25% due to adverse events. At 5 years, retention on agents was: adalimumab (77.2%), etanercept (69.6%) and infliximab (16.7%). Retention on adalimumab was significantly higher than infliximab (p<0.001), but did not differ between adalimumab and etanercept, or etanercept and infliximab. CONCLUSION: In a real-world setting, retention on infliximab was significantly lower than adalimumab. en
dc.publisher New Zealand Medical Association en
dc.relation.ispartofseries New Zealand Medical Journal en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Retention on anti-tumour necrosis factor therapy: the Waikato experience en
dc.type Journal Article en
pubs.issue 1415 en
pubs.begin-page 34 en
pubs.volume 128 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: New Zealand Medical Association en en
pubs.end-page 40 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 487843 en
pubs.record-created-at-source-date 2015-05-29 en

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