Human adipose-derived stem cells: Isolation, characterization and applications in surgery

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dc.contributor.author Locke, Michelle en
dc.contributor.author Windsor, John en
dc.contributor.author Dunbar, Peter en
dc.date.accessioned 2015-07-28T22:34:01Z en
dc.date.available 2008-07-12 en
dc.date.issued 2009 en
dc.identifier.citation ANZ Journal of Surgery, 2009, 79 (4), pp. 235 - 244 (10) en
dc.identifier.issn 1445-1433 en
dc.identifier.uri http://hdl.handle.net/2292/26483 en
dc.description.abstract The ideal stem cell for use in functional tissue engineering needs to be abundantly available, harvested with minimal morbidity, differentiated reliably down various pathways and able to be transplanted safely and efficaciously. Adult human adipose tissue contains a population of mesenchymal stem cells, termed ‘adipose-derived stem cells’ (ASC), which seem to fulfil most, if not all, of these criteria. ASC can be harvested readily, safely, and in relative abundance by modern liposuction techniques. They are capable of differentiating into other mesenchymal tissue types, including adipocytes, chondrocytes, myocytes and osteoblasts. They also show angiogenic properties, with recent evidence of a potential role in healing radiotherapy-damaged tissue, possibly due to their secretion of vascular endothelial growth factor. Similarly, they may have a role in healing chronic wounds, and as such are being investigated in phase 1 trials for their ability to aid healing of recurrent Crohn’s fistulae. Subsequently they have a wide range of potential clinical uses in all fields of surgery. This article reviews the current and potential clinical applications of ASC in relation to surgery, as well as methods for their isolation, differentiation and molecular characterization. en
dc.description.uri http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265406200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d en
dc.language English en
dc.publisher Royal Australasian College of Surgeons en
dc.relation.ispartofseries ANZ Journal of Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1445-1433/ http://olabout.wiley.com/WileyCDA/Section/id-820227.html en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Human adipose-derived stem cells: Isolation, characterization and applications in surgery en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1445-2197.2009.04852.x en
pubs.issue 4 en
pubs.begin-page 235 en
pubs.volume 79 en
dc.rights.holder Copyright: Royal Australasian College of Surgeons en
dc.identifier.pmid 19432707 en
pubs.author-url http://onlinelibrary.wiley.com/doi/10.1111/j.1445-2197.2009.04852.x/abstract en
pubs.end-page 244 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 90089 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1445-2197 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19432707 en


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