Human Adipose-derived Stem Cells (ASC): Separating promise from clinical need

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Show simple item record Feisst, Vaughan en Dunbar, Peter en Locke, Michelle en 2015-07-28T23:32:52Z en 2011-03 en
dc.identifier.citation Stem Cells, 2011, 29 (3), pp. 404 - 411 (8) en
dc.identifier.uri en
dc.description.abstract Human adipose-derived stem cells (ASCs) have become an increasing interest to both stem cell biologists and clinicians because of their potential to differentiate into adipogenic, osteogenic, chondrogenic, and other mesenchymal lineages, as well as other clinically useful properties attributed to them, such as stimulation of angiogenesis and suppression of inflammation. ASCs have already been used in a number of clinical trials, and some successful outcomes have been reported, especially in tissue reconstruction. However, a critical review of the literature reveals considerable uncertainty about the true clinical potential of human ASC. First, the surgical needs that ASC might answer remain relatively few, given the current difficulties in scaling up ASC-based tissue engineering to a clinically useful volume. Second, the differentiation of ASC into cell lineages apart from adipocytes has not been conclusively demonstrated in many studies due to the use of rather simplistic approaches to the confirmation of differentiation, such as the use of nonspecific histological dyes, or a small number of molecular markers of uncertain significance. Third, the ASC prepared from human lipoaspirate for different studies differ in purity and molecular phenotype, with many studies using cell preparations that are likely to contain heterogeneous populations of cells, making it uncertain whether ASC themselves are responsible for effects observed. Hence, while one clinical application already looks convincing, the full clinical potential of ASC awaits much deeper investigation of their fundamental biology. en
dc.language English en
dc.publisher AlphaMed Press / John Wiley & Sons en
dc.relation.ispartofseries Stem Cells en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Human Adipose-derived Stem Cells (ASC): Separating promise from clinical need en
dc.type Journal Article en
dc.identifier.doi 10.1002/stem.593 en
pubs.issue 3 en
pubs.begin-page 404 en
pubs.volume 29 en
dc.rights.holder Copyright: AlphaMed Press / John Wiley & Sons en
dc.identifier.pmid 21218444 en en
pubs.end-page 411 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 199789 en Medical and Health Sciences en School of Medicine en Surgery Department en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-01-19 en

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