Data sharing for pharmacokinetic studies

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dc.contributor.author Anderson, Brian en
dc.contributor.author Merry, Alan en
dc.date.accessioned 2015-07-31T00:39:14Z en
dc.date.issued 2009 en
dc.identifier.citation Paediatric Anaesthesia, 2009, 19 (10), pp. 1005 - 1010 en
dc.identifier.issn 1155-5645 en
dc.identifier.uri http://hdl.handle.net/2292/26531 en
dc.description.abstract Pooling data from different pediatric studies can provide a single robust pharmacokinetic analysis that allows covariate analysis and hypothesis testing. Data sharing should be driven by the altruistic purpose of improving drug understanding to the clinical benefit of children. Electronic communications have rendered the sharing of data relatively easy, and data sharing within the wider scientific community has become commonplace. Data sharing allows verification of results, save costs and time, allows new interpretation of old data, and can fulfill teaching benefits. It may stimulate cooperative competition between researchers and allow individual researchers to concentrate on unique aspects of the scientific puzzle. However, there is occasionally a reluctance to share, in part because of fear of others stealing the hard work of a research group, which may not be recognized in subsequent publications that reuse data. Providing data may require additional effort for presentation in a suitable format. Data may be abused or used for purposes other than those for which they were collected. Propriety claims may limit access to industry-sponsored drug research. The question of who has ownership of data is contentious. Investigators often consider data they have collected to be their own property. Reputations and grants may be hinge on ownership of a data set. However, other team members, institutions, funding agencies, and the public also have a stake. The difficulties identified in the general scientific community also apply to data sharing for pediatric pharmacokinetic studies. There are few clearly established rules at present, and consideration of the issues hinges on ethical and philosophical arguments. The development of databases will depend on collaboration and cooperation and greater clarity and consensus over appropriate processes and procedures. en
dc.relation.ispartofseries Paediatric Anaesthesia en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://olabout.wiley.com/WileyCDA/Section/id-820227.html http://www.sherpa.ac.uk/romeo/issn/1155-5645/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Data sharing for pharmacokinetic studies en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1460-9592.2009.03051.x en
pubs.issue 10 en
pubs.begin-page 1005 en
pubs.volume 19 en
dc.identifier.pmid 19558615 en
pubs.end-page 1010 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 85754 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Anaesthesiology en
dc.identifier.eissn 1460-9592 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19558615 en


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