Quantifying normal geometric variation in human pulmonary lobar geometry from high resolution computed tomography

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dc.contributor.author Chan, HF en
dc.contributor.author Clark, Alys en
dc.contributor.author Hoffman, EA en
dc.contributor.author Malcolm, DT en
dc.contributor.author Tawhai, Merryn en
dc.date.accessioned 2015-08-16T22:35:54Z en
dc.date.issued 2015-05 en
dc.identifier.citation Journal of Biomechanical Engineering, 2015, 137 (5) en
dc.identifier.issn 0148-0731 en
dc.identifier.uri http://hdl.handle.net/2292/26729 en
dc.description.abstract Previous studies of the ex vivo lung have suggested significant intersubject variability in lung lobe geometry. A quantitative description of normal lung lobe shape would therefore have value in improving the discrimination between normal population variability in shape and pathology. To quantify normal human lobe shape variability, a principal component analysis (PCA) was performed on high resolution computed tomography (HRCT) imaging of the lung at full inspiration. Volumetric imaging from 22 never-smoking subjects (10 female and 12 male) with normal lung function was included in the analysis. For each subject, an initial finite element mesh geometry was generated from a group of manually selected nodes that were placed at distinct anatomical locations on the lung surface. Each mesh used cubic shape functions to describe the surface curvilinearity, and the mesh was fitted to surface data for each lobe. A PCA was performed on the surface meshes for each lobe. Nine principal components (PCs) were sufficient to capture >90% of the normal variation in each of the five lobes. The analysis shows that lobe size can explain between 20% and 50% of intersubject variability, depending on the lobe considered. Diaphragm shape was the next most significant intersubject difference. When the influence of lung size difference is removed, the angle of the fissures becomes the most significant shape difference, and the variability in relative lobe size becomes important. We also show how a lobe from an independent subject can be projected onto the study population's PCs, demonstrating potential for abnormalities in lobar geometry to be defined in a quantitative manner. en
dc.format.medium Print-Electronic en
dc.language English en
dc.publisher American Society of Mechanical Engineers en
dc.relation.ispartofseries Journal of Biomechanical Engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0148-0731/ https://www.asme.org/shop/journals/administration/permissions en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Quantifying normal geometric variation in human pulmonary lobar geometry from high resolution computed tomography en
dc.type Journal Article en
dc.identifier.doi 10.1115/1.4029919 en
pubs.issue 5 en
pubs.volume 137 en
dc.rights.holder Copyright: American Society of Mechanical Engineers en
dc.identifier.pmid 25727935 en
pubs.author-url http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleID=2191152 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Journal Article en
pubs.subtype Research Support, Non-U.S. Gov't en
pubs.subtype Research Support, N.I.H., Extramural en
pubs.subtype Article en
pubs.elements-id 478369 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
dc.identifier.eissn 1528-8951 en
pubs.number 051010 en
pubs.record-created-at-source-date 2015-08-17 en
pubs.dimensions-id 25727935 en

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