dc.contributor.advisor |
Thorne, P |
en |
dc.contributor.author |
Affendi, AS |
en |
dc.date.accessioned |
2015-09-28T21:56:06Z |
en |
dc.date.issued |
2015 |
en |
dc.identifier.citation |
2015 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/27072 |
en |
dc.description |
Full text is available to authenticated members of The University of Auckland only. |
en |
dc.description.abstract |
The cochlear nucleus (CN) is a structure that is situated in the brainstem, acting as a first stage in the ascending auditory pathway to higher centers in the brain. The CN consists of 2 main divisions, the dorsal cochlear nucleus (DCN) and the ventral cochlear nucleus (VCN). The DCN and VCN are involved in relaying information to the auditory centers in the brain for sound localization and sound identification. Within the CN there are different populations of neurons, which have varied responses to sound stimulation, contributing to the ability for features of different sounds to be detected. The different CN cells create afferent and efferent systems, which contribute to our perception of different sounds in our environment. Glial cells are supporting cells, which play important supporting roles throughout most of the central nervous system. There are many different types of glial cells including astrocytes, oligodendrocytes, ependymal cells and radial glia cells. This thesis investigates the development of the mouse CN, and the role that glial cells play during this developmental process. The developmental ages P0-P22 was used in this research. Immunohistochemistry techniques combined with confocal laser microscopy allowed for the structural aspects of the CN to be observed, and also for the developmental expression of the different types of glial cells within the divisions of the CN. Results showed that the structures of the DCN and VCN can be visualized at different developmental ages, however the structures in the older ages are more defined. In addition, at different developmental ages the distribution of glial cells varies in both the DCN and VCN. The ependymal layer situated at the lateral edges of the CN show the most glial staining. At the younger ages, glial cells can be seen to be more abundant in the molecular layer of the DCN and less staining in the fusiform and deep layer. The molecular layer also shows more glial projections compared to the other layers. The differences in glial cells projections indicate that they may play a significant role in development of CN, such as guiding the migration of CN cells to their mature positions. |
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dc.publisher |
ResearchSpace@Auckland |
en |
dc.relation.ispartof |
Masters Thesis - University of Auckland |
en |
dc.relation.isreferencedby |
UoA99264812913302091 |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights |
Restricted Item. Available to authenticated members of The University of Auckland. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ |
en |
dc.title |
Glial Cells In The Developing Cochlear Nucleus |
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dc.type |
Thesis |
en |
thesis.degree.discipline |
Audiology |
en |
thesis.degree.grantor |
The University of Auckland |
en |
thesis.degree.level |
Masters |
en |
dc.rights.holder |
Copyright: The Author |
en |
pubs.elements-id |
499199 |
en |
pubs.record-created-at-source-date |
2015-09-29 |
en |
dc.identifier.wikidata |
Q112907908 |
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