Long-term potentiation (LTP) of human sensory-evoked potentials

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dc.contributor.author Kirk, Ian en
dc.contributor.author McNair, NA en
dc.contributor.author Hamm, Jeffrey en
dc.contributor.author Clapp, WC en
dc.contributor.author Mathalon, DH en
dc.contributor.author Cavus, I en
dc.contributor.author Teyler, TJ en
dc.date.accessioned 2015-10-05T20:09:37Z en
dc.date.issued 2010 en
dc.identifier.citation Wiley Interdisciplinary Reviews: Cognitive Science, 2010, 1 (5), pp. 766 - 773 (8) en
dc.identifier.issn 1939-5078 en
dc.identifier.uri http://hdl.handle.net/2292/27144 en
dc.description.abstract Long-term potentiation (LTP) is the principal candidate synaptic mechanism underlying learning and memory, and has been studied extensively at the cellular and molecular level in laboratory animals. Inquiry into the functional significance of LTP has been hindered by the absence of a human model as, until recently, LTP has only been directly demonstrated in humans in isolated cortical tissue obtained from patients undergoing surgery, where it displays properties identical to those seen in non-human preparations. In this brief review, we describe the results of paradigms recently developed in our laboratory for inducing LTP like changes in visual-, and auditory-evoked potentials. We describe how rapid, repetitive presentation of sensory stimuli leads to a persistent enhancement of components of sensory-evoked potential in normal humans. Experiments to date, investigating the locus, stimulus specificity, and NMDA receptor dependence of these LTP-like changes suggest that they have the essential characteristics of LTP seen in experimental animals. The ability to elicit LTP from non-surgical patients will provide a human model system allowing the detailed examination of synaptic plasticity in normal subjects and may have future clinical applications in the assessment of cognitive disorders. en
dc.description.uri http://wires.wiley.com/WileyCDA/WiresArticle/wisId-WCS62.html en
dc.language English en
dc.publisher John Wiley & Sons en
dc.relation.ispartofseries Wiley Interdisciplinary Reviews: Cognitive Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1939-5078/ http://olabout.wiley.com/WileyCDA/Section/id-820227.html en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Long-term potentiation (LTP) of human sensory-evoked potentials en
dc.type Journal Article en
dc.identifier.doi 10.1002/wcs.62 en
pubs.issue 5 en
pubs.begin-page 766 en
pubs.volume 1 en
dc.rights.holder Copyright: John Wiley & Sons en
pubs.author-url http://onlinelibrary.wiley.com/doi/10.1002/wcs.62/abstract en
pubs.end-page 773 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 96951 en
pubs.org-id Science en
pubs.org-id Psychology en
dc.identifier.eissn 1939-5086 en
pubs.record-created-at-source-date 2010-09-01 en

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