It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life

Show simple item record McGregor, Robin en Cameron-Smith, David en Poppitt, Sally en 2015-10-13T23:17:57Z en 2014-01 en
dc.identifier.citation Longevity and Healthspan, 2014, 3 (1), pp. 9 en
dc.identifier.uri en
dc.description.abstract Worldwide estimates predict 2 billion people will be aged over 65 years by 2050. A major current challenge is maintaining mobility and quality of life into old age. Impaired mobility is often a precursor of functional decline, disability and loss of independence. Sarcopenia which represents the age-related decline in muscle mass is a well-established factor associated with mobility limitations in older adults. However, there is now evidence that not only changes in muscle mass but other factors underpinning muscle quality including composition, metabolism, aerobic capacity, insulin resistance, fat infiltration, fibrosis and neural activation may also play a role in the decline in muscle function and impaired mobility associated with ageing. Importantly, changes in muscle quality may precede loss of muscle mass and therefore provide new opportunities for the assessment of muscle quality particularly in middle-aged adults who could benefit from interventions to improve muscle function. This review will discuss the accumulating evidence that in addition to muscle mass, factors underpinning muscle quality influence muscle function and mobility with age. Further development of tools to assess muscle quality in community settings is needed. Preventative diet, exercise or treatment interventions particularly in middle-aged adults at the low end of the spectrum of muscle function may help preserve mobility in later years and improve healthspan. en
dc.format.medium Electronic-eCollection en
dc.language eng en
dc.publisher BioMed Central en
dc.relation.ispartofseries Longevity and Healthspan en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life en
dc.type Journal Article en
dc.identifier.doi 10.1186/2046-2395-3-9 en
pubs.issue 1 en
pubs.begin-page 9 en
pubs.volume 3 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: BioMed Central en
dc.identifier.pmid 25520782 en
pubs.end-page 9 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 471229 en Science en Biological Sciences en
dc.identifier.eissn 2046-2395 en
pubs.record-created-at-source-date 2015-10-14 en
pubs.dimensions-id 25520782 en

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