Acute Biphasic Effects of Ayahuasca

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dc.contributor.author Schenberg, EE en
dc.contributor.author Alexandre, JFM en
dc.contributor.author Filev, R en
dc.contributor.author Cravo, AM en
dc.contributor.author Sato, JR en
dc.contributor.author Muthukumaraswamy, Suresh en
dc.contributor.author Yonamine, M en
dc.contributor.author Waguespack, M en
dc.contributor.author Lomnicka, I en
dc.contributor.author Barker, SA en
dc.contributor.author da Silveira, DX en
dc.contributor.editor Chialvo, DR en
dc.date.accessioned 2015-10-23T04:03:19Z en
dc.date.issued 2015-09-30 en
dc.identifier.citation PLOS ONE 10(9):27 pages Article number e0137202 30 Sep 2015 en
dc.identifier.uri http://hdl.handle.net/2292/27291 en
dc.description.abstract Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca's compounds and their metabolites in the systemic circulation we found ayahuasca to induce a biphasic effect in the brain. This effect was composed of reduced power in the alpha band (8–13 Hz) after 50 minutes from ingestion of the brew and increased slow- and fast-gamma power (30–50 and 50–100 Hz, respectively) between 75 and 125 minutes. Alpha power reductions were mostly located at left parieto-occipital cortex, slow-gamma power increase was observed at left centro-parieto-occipital, left fronto-temporal and right frontal cortices while fast-gamma increases were significant at left centro-parieto-occipital, left fronto-temporal, right frontal and right parieto-occipital cortices. These effects were significantly associated with circulating levels of ayahuasca’s chemical compounds, mostly N,N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine and some of their metabolites. An interpretation based on a cognitive and emotional framework relevant to the ritual use of ayahuasca, as well as it's potential therapeutic effects is offered. en
dc.relation.ispartofseries PLOS ONE en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1932-6203/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.title Acute Biphasic Effects of Ayahuasca en
dc.type Journal Article en
dc.identifier.doi 10.1371/journal.pone.0137202 en
pubs.issue 9 en
pubs.volume 10 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 26421727 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 501978 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
dc.identifier.eissn 1932-6203 en
pubs.number e0137202 en
pubs.record-created-at-source-date 2015-10-23 en
pubs.dimensions-id 26421727 en


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